Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy

B. Myrup, P. Rossing, T. Jensen, H.H. Parving, Gunhild Kofoed Hølmer, J. Gram, C. Kluft, J. Jespersen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Objective: We studied the effect of a diet supplementation with fish oil in insulin-dependent diabetic patients with nephropathy in order to evaluate whether abnormal transcapillary escape rate of albumin and procoagulant activity in these patients could be modified. Methods: A double-blind, randomized, controlled study was carried out at a tertiary referral centre. The subjects were 29 insulin-dependent diabetic patients with nephropathy. One year of fish oil supplementation (4.6 g n-3 fatty acids/day) was compared with placebo (olive oil). The main outcome measures were N-3 fatty acid proportions of platelet lipids, transcapillary escape rate of albumin, prothrombin fragment 1+2, thrombin-antithrombin complexes, markers of fibrinolysis, fibrinogen, factor VII antigen and activity, thrombomodulin, von Willebrand factor, platelet factor 4 and beta -thromboglobulin. These were measured every 6 months. Results: Neither transcapillary escape rate of albumin (7.4 (median) (5.0-9.8) (range) % vs. 7.0 (4.6- 10.6) %) nor prothrombin fragment 1+2 (0.97 (0.72-2.40)nmol/L vs. 1.01 (0.59-3.11)nmol/L) changed after 12 months of fish oil supplementation. Conclusion: Increased transcapillary escape rate of albumin and activity could not be modified during diet supplementation with fish oil in insulin-dependent diabetic patients with nephropathy.
    Original languageEnglish
    JournalScandinavian Journal of Clinical & Laboratory Investigation
    Volume61
    Issue number5
    Pages (from-to)349-356
    ISSN0036-5513
    DOIs
    Publication statusPublished - 2001

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