Label-free monitoring of diffusion in microfluidics

Kristian Tølbøl Sørensen, Anders Kristensen

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    Abstract

    Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa).
    Original languageEnglish
    Article number329
    JournalMicromachines
    Volume8
    Issue number11
    Number of pages7
    ISSN2072-666X
    DOIs
    Publication statusPublished - 2017

    Bibliographical note

    © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

    Keywords

    • optofluidics
    • microfluidics
    • diffusion
    • convection
    • mixing
    • refractive index
    • label-free
    • Mechanical engineering and machinery
    • TJ1-1570
    • Biological Materials
    • Microfluidics
    • Heat Transfer
    • Light and Optics
    • Chemical Operations
    • Convection
    • Diffusion
    • Label-free
    • Mixing
    • Optofluidics
    • Refractive index
    • Body fluids
    • Heat convection
    • Bovine serum albumins
    • Concentration gradients
    • Integrated photonics
    • Label free
    • Label-free monitoring
    • Opto-fluidics
    • Real-time detection
    • Spatial resolution

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