Label Free Chromosome Translocation Detection with Silicon nanowires

Dorota Kwasny, Karsten Brandt Andersen, Kasper Bayer Frøhling, Asli Silahtaroglu, Zeynep Tumer, Jaime Castillo, Winnie Edith Svendsen

    Research output: Contribution to conferencePosterResearchpeer-review

    Abstract

    HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method is a Fluorescent In Situ Hybridization, which is laborious and involves use of expensive reagents [1]. Here we present a label free technique for detection of chromosome translocations. As a proof of concept detection of chromosome translocation between chromosome 3 (Chr3) and chromosome 9 (Chr9) was chosen.
    Original languageEnglish
    Publication date2012
    Number of pages1
    Publication statusPublished - 2012
    EventEMBS Micro- and Nanoengineering Conference - Ka'anapali, United States
    Duration: 3 Dec 20127 Dec 2012

    Conference

    ConferenceEMBS Micro- and Nanoengineering Conference
    CountryUnited States
    CityKa'anapali
    Period03/12/201207/12/2012

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