Label Free Chromosome Translocation Detection with Silicon nanowires

Dorota Kwasny; Karsten Brandt Andersen; Kasper Bayer Frøhling; Asli Silahtaroglu; Zeynep  Tumer; Jaime Castillo; Winnie Edith Svendsen

Label Free Chromosome Translocation Detection with Silicon nanowires

Dorota Kwasny, Karsten Brandt Andersen, Kasper Bayer Frøhling, Asli Silahtaroglu, Zeynep Tumer, Jaime Castillo, Winnie Edith Svendsen

Research output: Contribution to conference › Poster › Research › peer-review

Abstract

HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method is a Fluorescent In Situ Hybridization, which is laborious and involves use of expensive reagents [1]. Here we present a label free technique for detection of chromosome translocations. As a proof of concept detection of chromosome translocation between chromosome 3 (Chr3) and chromosome 9 (Chr9) was chosen.

Original language	English
Publication date	2012
Number of pages	1
Publication status	Published - 2012
Event	EMBS Micro- and Nanoengineering Conference - Ka'anapali, United States Duration: 3 Dec 2012 → 7 Dec 2012

Conference

Conference	EMBS Micro- and Nanoengineering Conference
Country/Territory	United States
City	Ka'anapali
Period	03/12/2012 → 07/12/2012

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title = "Label Free Chromosome Translocation Detection with Silicon nanowires",

abstract = "HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method is a Fluorescent In Situ Hybridization, which is laborious and involves use of expensive reagents [1]. Here we present a label free technique for detection of chromosome translocations. As a proof of concept detection of chromosome translocation between chromosome 3 (Chr3) and chromosome 9 (Chr9) was chosen.",

author = "Dorota Kwasny and Andersen, {Karsten Brandt} and Fr{\o}hling, {Kasper Bayer} and Asli Silahtaroglu and Zeynep Tumer and Jaime Castillo and Svendsen, {Winnie Edith}",

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note = "EMBS Micro- and Nanoengineering Conference, MNMC ; Conference date: 03-12-2012 Through 07-12-2012",

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T1 - Label Free Chromosome Translocation Detection with Silicon nanowires

AU - Kwasny, Dorota

AU - Andersen, Karsten Brandt

AU - Frøhling, Kasper Bayer

AU - Silahtaroglu, Asli

AU - Tumer, Zeynep

AU - Castillo, Jaime

AU - Svendsen, Winnie Edith

PY - 2012

Y1 - 2012

N2 - HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method is a Fluorescent In Situ Hybridization, which is laborious and involves use of expensive reagents [1]. Here we present a label free technique for detection of chromosome translocations. As a proof of concept detection of chromosome translocation between chromosome 3 (Chr3) and chromosome 9 (Chr9) was chosen.

AB - HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method is a Fluorescent In Situ Hybridization, which is laborious and involves use of expensive reagents [1]. Here we present a label free technique for detection of chromosome translocations. As a proof of concept detection of chromosome translocation between chromosome 3 (Chr3) and chromosome 9 (Chr9) was chosen.

M3 - Poster

T2 - EMBS Micro- and Nanoengineering Conference

Y2 - 3 December 2012 through 7 December 2012

ER -

Label Free Chromosome Translocation Detection with Silicon nanowires

Abstract

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UN SDGs

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