Label-free and selective nonlinear fiber-optical biosensing

Johan Raunkjær Ott, Mikkel Heuck, Christian Agger, Per Dalgaard Rasmussen, Ole Bang

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We demonstrate that the inherent nonlinearity of a microstructured optical fiber (MOF) may be used to achieve label-free selective biosensing, thereby eliminating the need for post-processing of the fiber. This first nonlinear biosensor utilizes a change in the modulational instability (MI) gain spectrum (a shift of the Stokes- or anti-Stokes wavelength) caused by the selective capture of biomolecules by a sensor layer immobilised on the walls of the holes in the fiber. We find that such changes in the MI gain spectrum can be made detectable, and that engineering of the dispersion is important for optimizing the sensitivity. The nonlinear sensor shows a sensitivity of around 10.4nm/nm, defined as the shift in resonance wavelength per nm biolayer, which is a factor of 7.5 higher than the hitherto only demonstrated label-free MOF biosensor.
Original languageEnglish
JournalOptics Express
Volume16
Issue number25
Pages (from-to)20834-20847
ISSN1094-4087
DOIs
Publication statusPublished - 2008

Cite this

Ott, J. R., Heuck, M., Agger, C., Rasmussen, P. D., & Bang, O. (2008). Label-free and selective nonlinear fiber-optical biosensing. Optics Express, 16(25), 20834-20847. https://doi.org/10.1364/OE.16.020834
Ott, Johan Raunkjær ; Heuck, Mikkel ; Agger, Christian ; Rasmussen, Per Dalgaard ; Bang, Ole. / Label-free and selective nonlinear fiber-optical biosensing. In: Optics Express. 2008 ; Vol. 16, No. 25. pp. 20834-20847.
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Ott, JR, Heuck, M, Agger, C, Rasmussen, PD & Bang, O 2008, 'Label-free and selective nonlinear fiber-optical biosensing', Optics Express, vol. 16, no. 25, pp. 20834-20847. https://doi.org/10.1364/OE.16.020834

Label-free and selective nonlinear fiber-optical biosensing. / Ott, Johan Raunkjær; Heuck, Mikkel; Agger, Christian; Rasmussen, Per Dalgaard; Bang, Ole.

In: Optics Express, Vol. 16, No. 25, 2008, p. 20834-20847.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - Label-free and selective nonlinear fiber-optical biosensing

AU - Ott, Johan Raunkjær

AU - Heuck, Mikkel

AU - Agger, Christian

AU - Rasmussen, Per Dalgaard

AU - Bang, Ole

PY - 2008

Y1 - 2008

N2 - We demonstrate that the inherent nonlinearity of a microstructured optical fiber (MOF) may be used to achieve label-free selective biosensing, thereby eliminating the need for post-processing of the fiber. This first nonlinear biosensor utilizes a change in the modulational instability (MI) gain spectrum (a shift of the Stokes- or anti-Stokes wavelength) caused by the selective capture of biomolecules by a sensor layer immobilised on the walls of the holes in the fiber. We find that such changes in the MI gain spectrum can be made detectable, and that engineering of the dispersion is important for optimizing the sensitivity. The nonlinear sensor shows a sensitivity of around 10.4nm/nm, defined as the shift in resonance wavelength per nm biolayer, which is a factor of 7.5 higher than the hitherto only demonstrated label-free MOF biosensor.

AB - We demonstrate that the inherent nonlinearity of a microstructured optical fiber (MOF) may be used to achieve label-free selective biosensing, thereby eliminating the need for post-processing of the fiber. This first nonlinear biosensor utilizes a change in the modulational instability (MI) gain spectrum (a shift of the Stokes- or anti-Stokes wavelength) caused by the selective capture of biomolecules by a sensor layer immobilised on the walls of the holes in the fiber. We find that such changes in the MI gain spectrum can be made detectable, and that engineering of the dispersion is important for optimizing the sensitivity. The nonlinear sensor shows a sensitivity of around 10.4nm/nm, defined as the shift in resonance wavelength per nm biolayer, which is a factor of 7.5 higher than the hitherto only demonstrated label-free MOF biosensor.

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DO - 10.1364/OE.16.020834

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