Lab-on-a-chip systems with integrated optics for biochemical applications

Klaus Bo Mogensen (Invited author), O Gustafsson (Invited author), Pedro Nunes (Invited author), Jörg Peter Kutter (Invited author)

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    Two different applications that take advantage of integrated planar waveguides will be shown. The first example is a silicon chips for capillary electrochromatography (CEC), where the fluidic part contains electrically insulated channels with an injection cross and a chromatography column of microfabricated pillars, while the optical part consists of ultraviolet transparent planar waveguides for absorbance detection in the plane of the chip and fiber couplers for easy connection to an external light source and a photodetector. Electrochromatographic separations have been performed using hydrophobic octyl chains (C-8) immobilized onto the pillar sidewalls as a stationary phase. This is the first time capillary electrochromatography has been shown on a chip with integrated waveguides for detection. In another chip, an array of pillars inside a microfluidic column that is designed for electrochromatography is used as an optofluidic filter (1 D photonic crystal) for on-column label-free refractive index detection. Conventional planar waveguides are furthermore integrated for coupling light in and out of the structure.
    Original languageEnglish
    Title of host publicationProceedings of SPIE
    Volume6898
    Publication date2008
    Publication statusPublished - 2008
    EventSilicon Photonics III -
    Duration: 1 Jan 2008 → …

    Conference

    ConferenceSilicon Photonics III
    Period01/01/2008 → …

    Keywords

    • UV absorbance detection
    • Chromatography
    • Photonic crystals
    • Refractive index detection
    • Planar waveguides

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