Kissing loops hide premature termination codons in pre-mRNAof selenoprotein genes and in genes containing programmedribosomal frameshifts

Steen Knudsen, Søren Brunak

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A novel RNA secondary structure that places the selenocysteine codon UGA in one hairpin and a donor splice site in another, has been discovered in selenoprotein genes. The presence of the structure resolves the discrepancy that the selenocysteine triplet, UGA, should block splicing. Without a specific signal such as the novel RNA secondary structure, selenoproteins could not be produced from genes containing intervening sequences.
    Original languageEnglish
    JournalR N A
    Volume3
    Pages (from-to)697-701
    ISSN1355-8382
    Publication statusPublished - 1997

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