A novel RNA secondary structure that places the selenocysteine codon UGA in one hairpin and a donor splice site in another, has been discovered in selenoprotein genes. The presence of the structure resolves the discrepancy that the selenocysteine triplet, UGA, should block splicing. Without a specific signal such as the novel RNA secondary structure, selenoproteins could not be produced from genes containing intervening sequences.
|Journal||R N A|
|Publication status||Published - 1997|