Kinetics of self-assembling microtubules: An 'inverse problem' in biochemistry

H. Flyvbjerg, E. Jobs, S. Leibler

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Experimental time series for a nonequilibrium reaction may in some cases contain sufficient data to determine a unique kinetic model for the reaction by a systematic mathematical analysis. As an example, a kinetic model for the self-assembly of microtubules is derived here from turbidity time series for solutions in which microtubules assemble. The model may be seen as a generalization of Oosawa's classical nucleation-polymerization model. It re-produces the experimental data with a four-stage nucleation process and a critical nucleus of 15 monomers.
    Original languageEnglish
    JournalProceedings of the National Academy of Science of the United States of America
    Volume93
    Issue number12
    Pages (from-to)5975-5979
    ISSN0027-8424
    DOIs
    Publication statusPublished - 1996

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