Abstract
Experimental time series for a nonequilibrium reaction may in some cases contain sufficient data to determine a unique kinetic model for the reaction by a systematic mathematical analysis. As an example, a kinetic model for the self-assembly of microtubules is derived here from turbidity time series for solutions in which microtubules assemble. The model may be seen as a generalization of Oosawa's classical nucleation-polymerization model. It re-produces the experimental data with a four-stage nucleation process and a critical nucleus of 15 monomers.
Original language | English |
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Journal | Proceedings of the National Academy of Science of the United States of America |
Volume | 93 |
Issue number | 12 |
Pages (from-to) | 5975-5979 |
ISSN | 0027-8424 |
DOIs | |
Publication status | Published - 1996 |