Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction

Silvia Martins; Cristobal N. Aguilar; Iliana de la Garza-Rodriguez; Solange I. Mussatto; Jose A.  Teixeira

doi:10.1002/jctb.2412

Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction

Silvia Martins, Cristobal N. Aguilar, Iliana de la Garza-Rodriguez, Solange I. Mussatto, Jose A. Teixeira

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

BACKGROUND: Nordihydroguaiaretic acid (NDGA) is a powerful antioxidant with biological activities of great interest in several health areas, including antiviral, cancer chemopreventive, and antitumorgenic. Little information is available on extraction methods of NDGA from Larrea tridentata. Hence, the aim of this study was to develop a rapid and effective microwave-assisted extraction (MAE) method for NDGA recovery from Larrea tridentata leaves, and to compare the results obtained with those found using conventional heat-reflux extraction (HRE).

RESULTS: Extraction time for similar NDGA yields was significantly reduced from 18 to 1 min when MAE was used instead of HRE. Optimum conditions for NDGA extraction (3.79 ± 0.65%) consisted in using 50% methanol as extraction solvent in a solid/liquid ratio of 1/10 g mL−1. Micrographs demonstrated that the improvement in NDGA extraction by MAE might be related to a greater extent of cell rupture of the plant material. Extracts obtained by MAE exhibited antiradical activity only slightly lower than those obtained by HRE.

CONCLUSIONS: MAE proved to be a faster and more efficient method for NDGA extraction from Larrea tridentata leaves than HRE. The better results for NDGA extraction by MAE might be explained by the greater extent of cell rupture of plant material during the extraction process.

Original language	English
Journal	Journal of Chemical Technology and Biotechnology
Volume	85
Pages (from-to)	1142-1147
ISSN	0268-2575
DOIs	https://doi.org/10.1002/jctb.2412
Publication status	Published - 2010
Externally published	Yes

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@article{3e3b6c96912f41ed8c686fba7349e68f,

title = "Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction",

abstract = "BACKGROUND: Nordihydroguaiaretic acid (NDGA) is a powerful antioxidant with biological activities of great interest in several health areas, including antiviral, cancer chemopreventive, and antitumorgenic. Little information is available on extraction methods of NDGA from Larrea tridentata. Hence, the aim of this study was to develop a rapid and effective microwave-assisted extraction (MAE) method for NDGA recovery from Larrea tridentata leaves, and to compare the results obtained with those found using conventional heat-reflux extraction (HRE).RESULTS: Extraction time for similar NDGA yields was significantly reduced from 18 to 1 min when MAE was used instead of HRE. Optimum conditions for NDGA extraction (3.79 ± 0.65%) consisted in using 50% methanol as extraction solvent in a solid/liquid ratio of 1/10 g mL−1. Micrographs demonstrated that the improvement in NDGA extraction by MAE might be related to a greater extent of cell rupture of the plant material. Extracts obtained by MAE exhibited antiradical activity only slightly lower than those obtained by HRE.CONCLUSIONS: MAE proved to be a faster and more efficient method for NDGA extraction from Larrea tridentata leaves than HRE. The better results for NDGA extraction by MAE might be explained by the greater extent of cell rupture of plant material during the extraction process.",

author = "Silvia Martins and Aguilar, {Cristobal N.} and {de la Garza-Rodriguez}, Iliana and Mussatto, {Solange I.} and Teixeira, {Jose A.}",

year = "2010",

doi = "10.1002/jctb.2412",

language = "English",

volume = "85",

pages = "1142--1147",

journal = "Journal of Chemical Technology and Biotechnology",

issn = "0268-2575",

publisher = "JohnWiley & Sons Ltd.",

}

Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction. / Martins, Silvia; Aguilar, Cristobal N.; de la Garza-Rodriguez, Iliana; Mussatto, Solange I.; Teixeira, Jose A. .

In: Journal of Chemical Technology and Biotechnology, Vol. 85, 2010, p. 1142-1147.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction

AU - Martins, Silvia

AU - Aguilar, Cristobal N.

AU - de la Garza-Rodriguez, Iliana

AU - Mussatto, Solange I.

AU - Teixeira, Jose A.

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Nordihydroguaiaretic acid (NDGA) is a powerful antioxidant with biological activities of great interest in several health areas, including antiviral, cancer chemopreventive, and antitumorgenic. Little information is available on extraction methods of NDGA from Larrea tridentata. Hence, the aim of this study was to develop a rapid and effective microwave-assisted extraction (MAE) method for NDGA recovery from Larrea tridentata leaves, and to compare the results obtained with those found using conventional heat-reflux extraction (HRE).RESULTS: Extraction time for similar NDGA yields was significantly reduced from 18 to 1 min when MAE was used instead of HRE. Optimum conditions for NDGA extraction (3.79 ± 0.65%) consisted in using 50% methanol as extraction solvent in a solid/liquid ratio of 1/10 g mL−1. Micrographs demonstrated that the improvement in NDGA extraction by MAE might be related to a greater extent of cell rupture of the plant material. Extracts obtained by MAE exhibited antiradical activity only slightly lower than those obtained by HRE.CONCLUSIONS: MAE proved to be a faster and more efficient method for NDGA extraction from Larrea tridentata leaves than HRE. The better results for NDGA extraction by MAE might be explained by the greater extent of cell rupture of plant material during the extraction process.

AB - BACKGROUND: Nordihydroguaiaretic acid (NDGA) is a powerful antioxidant with biological activities of great interest in several health areas, including antiviral, cancer chemopreventive, and antitumorgenic. Little information is available on extraction methods of NDGA from Larrea tridentata. Hence, the aim of this study was to develop a rapid and effective microwave-assisted extraction (MAE) method for NDGA recovery from Larrea tridentata leaves, and to compare the results obtained with those found using conventional heat-reflux extraction (HRE).RESULTS: Extraction time for similar NDGA yields was significantly reduced from 18 to 1 min when MAE was used instead of HRE. Optimum conditions for NDGA extraction (3.79 ± 0.65%) consisted in using 50% methanol as extraction solvent in a solid/liquid ratio of 1/10 g mL−1. Micrographs demonstrated that the improvement in NDGA extraction by MAE might be related to a greater extent of cell rupture of the plant material. Extracts obtained by MAE exhibited antiradical activity only slightly lower than those obtained by HRE.CONCLUSIONS: MAE proved to be a faster and more efficient method for NDGA extraction from Larrea tridentata leaves than HRE. The better results for NDGA extraction by MAE might be explained by the greater extent of cell rupture of plant material during the extraction process.

U2 - 10.1002/jctb.2412

DO - 10.1002/jctb.2412

M3 - Journal article

VL - 85

SP - 1142

EP - 1147

JO - Journal of Chemical Technology and Biotechnology

JF - Journal of Chemical Technology and Biotechnology

SN - 0268-2575

ER -

Kinetic study of nordihydroguaiaretic acid recovery from Larrea tridentata by microwave-assisted extraction

Abstract

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