Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B

Lene Maj Petersen; Tanja Thorskov Bladt; Claudia Duerr; Martina Seiffert; Jens Christian Frisvad; Charlotte Held Gotfredsen; Thomas Ostenfeld Larsen

doi:10.3390/molecules19079786

Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B

Lene Maj Petersen, Tanja Thorskov Bladt, Claudia Duerr, Martina Seiffert, Jens Christian Frisvad, Charlotte Held Gotfredsen, Thomas Ostenfeld Larsen

Department of Chemistry

German Cancer Research Center

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Abstract

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.

Original language	English
Journal	Molecules
Volume	19
Issue number	7
Pages (from-to)	9786-9797
Number of pages	12
ISSN	1420-3049
DOIs	https://doi.org/10.3390/molecules19079786
Publication status	Published - 2014

Bibliographical note

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Keywords

CHEMISTRY,
ASPERGILLUS-FLAVIPES
ENDOPHYTIC FUNGUS
ASPOCHALASIN-I
INHIBITOR
TERREUS
FERMENTATION
PENICILLIUM
CLAVATUS
ELEGANS
CELLS
cytochalasins
apergilli
Apsergillus sclerotioniger
chronic lymphocytic leukemia
STRUCTURAL analysis (Science)

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title = "Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B",

abstract = "Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.",

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author = "Petersen, {Lene Maj} and Bladt, {Tanja Thorskov} and Claudia Duerr and Martina Seiffert and Frisvad, {Jens Christian} and Gotfredsen, {Charlotte Held} and Larsen, {Thomas Ostenfeld}",

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AU - Petersen, Lene Maj

AU - Bladt, Tanja Thorskov

AU - Duerr, Claudia

AU - Seiffert, Martina

AU - Frisvad, Jens Christian

AU - Gotfredsen, Charlotte Held

AU - Larsen, Thomas Ostenfeld

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AB - Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.

KW - CHEMISTRY,

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KW - ENDOPHYTIC FUNGUS

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KW - TERREUS

KW - FERMENTATION

KW - PENICILLIUM

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KW - apergilli

KW - Apsergillus sclerotioniger

KW - chronic lymphocytic leukemia

KW - STRUCTURAL analysis (Science)

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JO - Molecules

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Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B

Abstract

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Keywords

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