Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins - Sclerotionigrin A and B

Lene Maj Petersen, Tanja Thorskov Bladt, Claudia Duerr, Martina Seiffert, Jens Christian Frisvad, Charlotte Held Gotfredsen, Thomas Ostenfeld Larsen

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Abstract

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
Original languageEnglish
JournalMolecules
Volume19
Issue number7
Pages (from-to)9786-9797
Number of pages12
ISSN1420-3049
DOIs
Publication statusPublished - 2014

Bibliographical note

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Keywords

  • CHEMISTRY,
  • ASPERGILLUS-FLAVIPES
  • ENDOPHYTIC FUNGUS
  • ASPOCHALASIN-I
  • INHIBITOR
  • TERREUS
  • FERMENTATION
  • PENICILLIUM
  • CLAVATUS
  • ELEGANS
  • CELLS
  • cytochalasins
  • apergilli
  • Apsergillus sclerotioniger
  • chronic lymphocytic leukemia
  • STRUCTURAL analysis (Science)

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