Isolation and NMR Characterization of Fumonisin B-2 and a New Fumonisin B-6 from Aspergillus niger

Maria Månsson, Marie Louise Klejnstrup, Richard Kerry Phipps, Kristian Fog Nielsen, Jens Christian Frisvad, Charlotte Held Gotfredsen, Thomas Ostenfeld Larsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A new fumonisin, fumonisin B-6 (1), has been isolated by cation-exchange and reverse-phase chromatography, together with fumonisin B-2 (2), from,stationary cultures of the fungus Aspergillus niger NRRL 326. Analysis of mass spectrometric and NMR data determined that FB6 is a positional isomer of FBI and iso-FB1, having hydroxyl functions at C3, C4, and C5. Analysis of the NMR data for FB2 showed very similar chemical shift values when compared to an authentic Fusarium FB2 standard, strongly indicating identical molecules despite that an absolute stereochemical assignment of FB2 from A. niger was not possible.
Original languageEnglish
JournalJournal of Agricultural and Food Chemistry
Volume58
Issue number2
Pages (from-to)949-953
ISSN0021-8561
DOIs
Publication statusPublished - 2010

Keywords

  • Fumonisins
  • food safety
  • NMR
  • Aspergillus niger
  • mycotoxins

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