Is the pan-genome also a pan-selectome?

David Ussery, Francisco Rodriguez-Valera

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The comparative genomics of prokaryotes has shown the presence of conserved regions containing highly similar genes (the 'core genome') and other regions that vary in gene content (the 'flexible' regions). A significant part of the latter is involved in surface structures that are phage recognition targets. Another sizeable part provides for differences in niche exploitation. Metagenomic data indicates that natural populations of prokaryotes are composed of assemblages of clonal lineages or "meta-clones" that share a core of genes but contain a high diversity by varying the flexible component. This meta-clonal diversity is maintained by a collection of phages that equalize the populations by preventing any individual clonal lineage from hoarding common resources. Thus, this polyclonal assemblage and the phages preying upon them constitute natural selection units. © 2012 Rodriguez-Valera F et al.
    Original languageEnglish
    JournalF1000Research
    Volume1
    Issue number16
    ISSN2046-1402
    DOIs
    Publication statusPublished - 2012

    Keywords

    • article
    • bacterial genome
    • bacteriophage
    • bacterium
    • cell surface
    • clonal variation
    • gene targeting
    • genetic conservation
    • genetic selection
    • genomics
    • metagenomics
    • nonhuman
    • pan genomic
    • pan selectome
    • Pelagibacter ubique
    • Prochlorococcus
    • prokaryote
    • Synechococcus

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