Is Synthesizing MRI Contrast Useful for Inter-modality Analysis?

Juan Eugenio Iglesias, Ender Konukoglu, Darko Zikic, Ben Glocker, Koen Van Leemput, Bruce Fischl

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

Availability of multi-modal magnetic resonance imaging (MRI) databases opens up the opportunity to synthesize different MRI contrasts without actually acquiring the images. In theory such synthetic images have the potential to reduce the amount of acquisitions to perform certain analyses. However, to what extent they can substitute real acquisitions in the respective analyses is an open question. In this study, we used a synthesis method based on patch matching to test whether synthetic images can be useful in segmentation and inter-modality cross-subject registration of brain MRI. Thirty-nine T1 scans with 36 manually labeled structures of interest were used in the registration and segmentation of eight proton density (PD) scans, for which ground truth T1 data were also available. The results show that synthesized T1 contrast can considerably enhance the quality of non-linear registration compared with using the original PD data, and it is only marginally worse than using the original T1 scans. In segmentation, the relative improvement with respect to using the PD is smaller, but still statistically significant.
Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention – MICCAI 2013 : 16th International Conference, Nagoya, Japan, September 22-26, 2013, Proceedings, Part I
PublisherSpringer
Publication date2013
Pages631-638
ISBN (Print)978-3-642-40810-6
ISBN (Electronic)978-3-642-40811-3
DOIs
Publication statusPublished - 2013
Event16th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2013) - Nagoya, Japan
Duration: 22 Sep 201326 Sep 2013
http://www.miccai2013.org/

Conference

Conference16th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2013)
CountryJapan
CityNagoya
Period22/09/201326/09/2013
Internet address
SeriesLecture Notes in Computer Science
Volume8149
ISSN0302-9743

Keywords

  • Image segmentation
  • Magnetic resonance imaging

Cite this

Iglesias, J. E., Konukoglu, E., Zikic, D., Glocker, B., Van Leemput, K., & Fischl, B. (2013). Is Synthesizing MRI Contrast Useful for Inter-modality Analysis? In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2013: 16th International Conference, Nagoya, Japan, September 22-26, 2013, Proceedings, Part I (pp. 631-638). Springer. Lecture Notes in Computer Science, Vol.. 8149 https://doi.org/10.1007/978-3-642-40811-3_79