Irradiation of bioresorbable biomaterials for controlled surface degradation

M. Simpson, B.F. Gilmore, Arne Miller, Jakob Helt-Hansen, F.J. Buchanan

    Research output: Contribution to journalConference articleResearchpeer-review

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    Abstract

    Bioresorbable polymers increasingly are the materials of choice for implantable orthopaedic fixation devices. Controlled degradation of these polymers is vital for preservation of mechanical properties during tissue repair and controlled release of incorporated agents such as osteoconductive or anti-microbial additives. The work outlined in this paper investigates the use of low energy electron beam irradiation to surface modify polyhydroxyacid samples incorporating beta tricalcium phosphate (β-TCP). This work uniquely demonstrates that surface modification of bioresorbable polymers through electron beam irradiation allows for the early release of incorporated agents such as bioactive additives. Samples were e-beam irradiated at an energy of 125 keV and doses of either 150 kGy or 500 kGy. Irradiated and non-irradiated samples were degraded in phosphate buffered saline (PBS), to simulate bioresorption, followed by characterisation. The results show that low energy e-beam irradiation enhances surface hydrolytic degradation in comparison to bulk and furthermore allows for earlier release of incorporated calcium via dissolution into the surrounding medium.
    Original languageEnglish
    JournalRadiation Physics and Chemistry
    Volume94
    Pages (from-to)211–216
    ISSN0969-806X
    DOIs
    Publication statusPublished - 2014
    Event10th Meeting of the Ionizing Radiation and Polymers Symposium - Cracow, Poland
    Duration: 14 Oct 201219 Oct 2012
    Conference number: 10
    http://www.irap2012.pl/

    Conference

    Conference10th Meeting of the Ionizing Radiation and Polymers Symposium
    Number10
    CountryPoland
    CityCracow
    Period14/10/201219/10/2012
    Internet address

    Keywords

    • Bioresorbable polymer
    • Electron beam irradiation
    • Controlled surface degradation
    • Controlled release

    Cite this

    Simpson, M. ; Gilmore, B.F. ; Miller, Arne ; Helt-Hansen, Jakob ; Buchanan, F.J. / Irradiation of bioresorbable biomaterials for controlled surface degradation. In: Radiation Physics and Chemistry. 2014 ; Vol. 94. pp. 211–216.
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    title = "Irradiation of bioresorbable biomaterials for controlled surface degradation",
    abstract = "Bioresorbable polymers increasingly are the materials of choice for implantable orthopaedic fixation devices. Controlled degradation of these polymers is vital for preservation of mechanical properties during tissue repair and controlled release of incorporated agents such as osteoconductive or anti-microbial additives. The work outlined in this paper investigates the use of low energy electron beam irradiation to surface modify polyhydroxyacid samples incorporating beta tricalcium phosphate (β-TCP). This work uniquely demonstrates that surface modification of bioresorbable polymers through electron beam irradiation allows for the early release of incorporated agents such as bioactive additives. Samples were e-beam irradiated at an energy of 125 keV and doses of either 150 kGy or 500 kGy. Irradiated and non-irradiated samples were degraded in phosphate buffered saline (PBS), to simulate bioresorption, followed by characterisation. The results show that low energy e-beam irradiation enhances surface hydrolytic degradation in comparison to bulk and furthermore allows for earlier release of incorporated calcium via dissolution into the surrounding medium.",
    keywords = "Bioresorbable polymer, Electron beam irradiation, Controlled surface degradation, Controlled release",
    author = "M. Simpson and B.F. Gilmore and Arne Miller and Jakob Helt-Hansen and F.J. Buchanan",
    year = "2014",
    doi = "10.1016/j.radphyschem.2013.09.002",
    language = "English",
    volume = "94",
    pages = "211–216",
    journal = "Radiation Physics and Chemistry",
    issn = "0969-806X",
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    Irradiation of bioresorbable biomaterials for controlled surface degradation. / Simpson, M.; Gilmore, B.F.; Miller, Arne; Helt-Hansen, Jakob; Buchanan, F.J.

    In: Radiation Physics and Chemistry, Vol. 94, 2014, p. 211–216.

    Research output: Contribution to journalConference articleResearchpeer-review

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    AU - Simpson, M.

    AU - Gilmore, B.F.

    AU - Miller, Arne

    AU - Helt-Hansen, Jakob

    AU - Buchanan, F.J.

    PY - 2014

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    AB - Bioresorbable polymers increasingly are the materials of choice for implantable orthopaedic fixation devices. Controlled degradation of these polymers is vital for preservation of mechanical properties during tissue repair and controlled release of incorporated agents such as osteoconductive or anti-microbial additives. The work outlined in this paper investigates the use of low energy electron beam irradiation to surface modify polyhydroxyacid samples incorporating beta tricalcium phosphate (β-TCP). This work uniquely demonstrates that surface modification of bioresorbable polymers through electron beam irradiation allows for the early release of incorporated agents such as bioactive additives. Samples were e-beam irradiated at an energy of 125 keV and doses of either 150 kGy or 500 kGy. Irradiated and non-irradiated samples were degraded in phosphate buffered saline (PBS), to simulate bioresorption, followed by characterisation. The results show that low energy e-beam irradiation enhances surface hydrolytic degradation in comparison to bulk and furthermore allows for earlier release of incorporated calcium via dissolution into the surrounding medium.

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    KW - Electron beam irradiation

    KW - Controlled surface degradation

    KW - Controlled release

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    JO - Radiation Physics and Chemistry

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