IRF8 dependent classical dendritic cells are essential for intestinal T cell homeostasis

Research output: Contribution to journalConference abstract in journal – Annual report year: 2017Researchpeer-review

Documents

View graph of relations

The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 dependent DCs have reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an almost complete absence of SI CD8ab+ andCD4+CD8aa+ T cells; the latter requiring b8 integrin expression by migratory IRF8 dependent CD103+CD11b- DCs. SI homing receptor induction was impaired during T cell priming in mesenteric lymph nodes (MLN), which correlated with a reduction in aldehyde dehydrogenase activity by SI derived MLN DCs, and inefficient T cell localization to the SI. Finally, mice with a DC deletion in IRF8 lacked intestinal T helper 1 (Th1) cells, and failed to support Th1 cell differentiation in MLN and mount Th1 responses to Trichuris muris infection. Collectively these results highlight multiple non-redundant roles for IRF8 dependent DCs in the maintenance of intestinal T cell homeostasis.
Original languageEnglish
JournalEuropean Journal of Immunology
Volume46
Issue numberSuppl. 1
Pages (from-to)946-946
ISSN0014-2980
Publication statusPublished - 2016
Event ICI 2016 International Congress of Immunology - Melbourne, Australia
Duration: 21 Aug 201626 Aug 2016

Conference

Conference ICI 2016 International Congress of Immunology
CountryAustralia
CityMelbourne
Period21/08/201626/08/2016

Download statistics

No data available

ID: 139473434