IRF8 dependent classical dendritic cells are essential for intestinal T cell homeostasis

K. Luda, Thorsten Joeris, E. K. Persson , Aymeric Marie Christian Rivollier, M. Demiri, Katarzyna Maria Sitnik, Lieneke Pool, J. B. Holm, F. Melo-Gonzalez, L. Richter, B. N. Lambrecht, Karsten Kristiansen, M. A. Travis, M. Svensson-Frej, K. Kotarsky, William Winston Agace

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    Abstract

    The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 dependent DCs have reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an almost complete absence of SI CD8ab+ andCD4+CD8aa+ T cells; the latter requiring b8 integrin expression by migratory IRF8 dependent CD103+CD11b- DCs. SI homing receptor induction was impaired during T cell priming in mesenteric lymph nodes (MLN), which correlated with a reduction in aldehyde dehydrogenase activity by SI derived MLN DCs, and inefficient T cell localization to the SI. Finally, mice with a DC deletion in IRF8 lacked intestinal T helper 1 (Th1) cells, and failed to support Th1 cell differentiation in MLN and mount Th1 responses to Trichuris muris infection. Collectively these results highlight multiple non-redundant roles for IRF8 dependent DCs in the maintenance of intestinal T cell homeostasis.
    Original languageEnglish
    JournalEuropean Journal of Immunology
    Volume46
    Issue numberSuppl. 1
    Pages (from-to)946-946
    ISSN0014-2980
    Publication statusPublished - 2016
    Event ICI 2016 International Congress of Immunology - Melbourne, Australia
    Duration: 21 Aug 201626 Aug 2016

    Conference

    Conference ICI 2016 International Congress of Immunology
    CountryAustralia
    CityMelbourne
    Period21/08/201626/08/2016

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