phuR intergenic mutation results in pleiotropic effects on global gene expression

Seyed Mohammad Hossein Khademi, Tina Wassermann, Oana Ciofu, Lars Jelsbak

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    Abstract

    We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.
    Original languageEnglish
    Title of host publicationProceedings of the ASM Conference on Pseudomonas 2015
    PublisherAmerican Society for Microbiology
    Publication date2015
    Pages126-127
    Article number126
    Publication statusPublished - 2015
    EventThe ASM Conference on Pseudomonas 2015 - Washington, DC, United States
    Duration: 8 Sep 201512 Sep 2015
    http://conferences.asm.org/index.php/2012-02-09-21-04-52/past-conferences/2-uncategorised/326-conference-scope-2015-pseudo

    Conference

    ConferenceThe ASM Conference on Pseudomonas 2015
    CountryUnited States
    CityWashington, DC
    Period08/09/201512/09/2015
    Internet address

    Cite this

    Khademi, S. M. H., Wassermann, T., Ciofu, O., & Jelsbak, L. (2015). phuR intergenic mutation results in pleiotropic effects on global gene expression. In Proceedings of the ASM Conference on Pseudomonas 2015 (pp. 126-127). [126] American Society for Microbiology.