phuR intergenic mutation results in pleiotropic effects on global gene expression

Seyed Mohammad Hossein Khademi, Tina Wassermann, Oana Ciofu, Lars Jelsbak

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

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    Abstract

    We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.
    Original languageEnglish
    Title of host publicationProceedings of the ASM Conference on Pseudomonas 2015
    PublisherAmerican Society for Microbiology
    Publication date2015
    Pages126-127
    Article number126
    Publication statusPublished - 2015
    EventThe ASM Conference on Pseudomonas 2015 - Washington, DC, United States
    Duration: 8 Sep 201512 Sep 2015
    http://conferences.asm.org/index.php/2012-02-09-21-04-52/past-conferences/2-uncategorised/326-conference-scope-2015-pseudo

    Conference

    ConferenceThe ASM Conference on Pseudomonas 2015
    CountryUnited States
    CityWashington, DC
    Period08/09/201512/09/2015
    Internet address

    Cite this

    Khademi, S. M. H., Wassermann, T., Ciofu, O., & Jelsbak, L. (2015). phuR intergenic mutation results in pleiotropic effects on global gene expression. In Proceedings of the ASM Conference on Pseudomonas 2015 (pp. 126-127). [126] American Society for Microbiology.
    Khademi, Seyed Mohammad Hossein ; Wassermann, Tina ; Ciofu, Oana ; Jelsbak, Lars. / phuR intergenic mutation results in pleiotropic effects on global gene expression. Proceedings of the ASM Conference on Pseudomonas 2015. American Society for Microbiology, 2015. pp. 126-127
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    abstract = "We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.",
    author = "Khademi, {Seyed Mohammad Hossein} and Tina Wassermann and Oana Ciofu and Lars Jelsbak",
    year = "2015",
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    Khademi, SMH, Wassermann, T, Ciofu, O & Jelsbak, L 2015, phuR intergenic mutation results in pleiotropic effects on global gene expression. in Proceedings of the ASM Conference on Pseudomonas 2015., 126, American Society for Microbiology, pp. 126-127, The ASM Conference on Pseudomonas 2015, Washington, DC, United States, 08/09/2015.

    phuR intergenic mutation results in pleiotropic effects on global gene expression. / Khademi, Seyed Mohammad Hossein; Wassermann, Tina; Ciofu, Oana; Jelsbak, Lars.

    Proceedings of the ASM Conference on Pseudomonas 2015. American Society for Microbiology, 2015. p. 126-127 126.

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

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    T1 - phuR intergenic mutation results in pleiotropic effects on global gene expression

    AU - Khademi, Seyed Mohammad Hossein

    AU - Wassermann, Tina

    AU - Ciofu, Oana

    AU - Jelsbak, Lars

    PY - 2015

    Y1 - 2015

    N2 - We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.

    AB - We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.

    M3 - Conference abstract in proceedings

    SP - 126

    EP - 127

    BT - Proceedings of the ASM Conference on Pseudomonas 2015

    PB - American Society for Microbiology

    ER -

    Khademi SMH, Wassermann T, Ciofu O, Jelsbak L. phuR intergenic mutation results in pleiotropic effects on global gene expression. In Proceedings of the ASM Conference on Pseudomonas 2015. American Society for Microbiology. 2015. p. 126-127. 126