phuR intergenic mutation results in pleiotropic effects on global gene expression

Seyed Mohammad Hossein Khademi; Tina Wassermann; Oana Ciofu; Lars Jelsbak

phuR intergenic mutation results in pleiotropic effects on global gene expression

Seyed Mohammad Hossein Khademi, Tina Wassermann, Oana Ciofu, Lars Jelsbak

University of Copenhagen

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

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Abstract

We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.

Original language	English
Title of host publication	Proceedings of the ASM Conference on Pseudomonas 2015
Publisher	American Society for Microbiology
Publication date	2015
Pages	126-127
Article number	126
Publication status	Published - 2015
Event	The ASM Conference on Pseudomonas 2015 - Washington, DC, United States Duration: 8 Sept 2015 → 12 Sept 2015 http://conferences.asm.org/index.php/2012-02-09-21-04-52/past-conferences/2-uncategorised/326-conference-scope-2015-pseudo

Conference

Conference	The ASM Conference on Pseudomonas 2015
Country/Territory	United States
City	Washington, DC
Period	08/09/2015 → 12/09/2015
Internet address	http://conferences.asm.org/index.php/2012-02-09-21-04-52/past-conferences/2-uncategorised/326-conference-scope-2015-pseudo

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title = "phuR intergenic mutation results in pleiotropic effects on global gene expression",

abstract = "We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin. ",

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phuR intergenic mutation results in pleiotropic effects on global gene expression. / Khademi, Seyed Mohammad Hossein; Wassermann, Tina; Ciofu, Oana et al.
Proceedings of the ASM Conference on Pseudomonas 2015. American Society for Microbiology, 2015. p. 126-127 126.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

TY - ABST

T1 - phuR intergenic mutation results in pleiotropic effects on global gene expression

AU - Khademi, Seyed Mohammad Hossein

AU - Wassermann, Tina

AU - Ciofu, Oana

AU - Jelsbak, Lars

PY - 2015

Y1 - 2015

N2 - We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.

AB - We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.

M3 - Conference abstract in proceedings

SP - 126

EP - 127

BT - Proceedings of the ASM Conference on Pseudomonas 2015

PB - American Society for Microbiology

T2 - The ASM Conference on Pseudomonas 2015

Y2 - 8 September 2015 through 12 September 2015

ER -

phuR intergenic mutation results in pleiotropic effects on global gene expression

Abstract

Conference

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