We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.
|Title of host publication||Proceedings of the ASM Conference on Pseudomonas 2015|
|Publisher||American Society for Microbiology|
|Publication status||Published - 2015|
|Event||The ASM Conference on Pseudomonas 2015 - Washington, DC, United States|
Duration: 8 Sep 2015 → 12 Sep 2015
|Conference||The ASM Conference on Pseudomonas 2015|
|Period||08/09/2015 → 12/09/2015|