Ionic liquid-based in situ product removal (ISPR) design exemplified for an ABE fermentation

Yuqiu Chen, Nipun Garg, Hao Luo, Georgios M Kontogeorgis, John M. Woodley*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Selecting an appropriate separation technique is essential for the application of in situ product removal (ISPR) technology in biological processes. In this work, a three-stage systematic design method is proposed as a guide to integrate ionic liquid (IL)-based separation techniques into ISPR. This design method combines the selection of a suitable ISPR processing scheme, the optimal design of an IL-based liquid-liquid extraction (LLE) system followed by process simulation and evaluation. As a proof of concept, results for a conventional acetone-butanol-ethanol (ABE) fermentation are presented (40,000 tone/year butanol production). In this application, ILs tetradecyl(trihexyl)phosphonium tetracyanoborate ([TDPh][TCB]) and tetraoctylammonium 2-methyl-1-naphthoate ([TOA] [MNaph]) are identified as the optimal solvents from computer-aided IL design (CAILD) method and reported experimental data, respectively. The dynamic simulation results for the fermentation process show that, the productivity of IL-based in situ (fed-batch) process and in situ (batch) process is around 2.7 and 1.8-fold that of base case. Additionally, the IL-based in situ (fed-batch) process and in situ (batch) process also have significant energy savings (79.6% and 77.6%) when compared to the base case.
Original languageEnglish
JournalBiotechnology Progress
ISSN8756-7938
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • ISPR
  • Ionic liquid
  • ABE fermentation
  • CAILD
  • Process design

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