Abstract
The advent of polymeric materials has significantly promoted the development
and rapid growth of various technologies in biomedical applications, such as tissue
engineering and controlled drug and gene delivery. Water-soluble polypeptides
bearing functional side chains and adopting stable secondary structures are a
new class of functional polymeric materials of potentially broad applications in
medicine and biotechnology. In this article, we summarize our recent effort on the
design and synthesis of the water-soluble 훼-helical ionic polypeptides originally
developed in our laboratory and highlight their applications in cell membrane
penetration and nonviral gene/small interfering RNA (siRNA) delivery.
and rapid growth of various technologies in biomedical applications, such as tissue
engineering and controlled drug and gene delivery. Water-soluble polypeptides
bearing functional side chains and adopting stable secondary structures are a
new class of functional polymeric materials of potentially broad applications in
medicine and biotechnology. In this article, we summarize our recent effort on the
design and synthesis of the water-soluble 훼-helical ionic polypeptides originally
developed in our laboratory and highlight their applications in cell membrane
penetration and nonviral gene/small interfering RNA (siRNA) delivery.
| Original language | English |
|---|---|
| Journal | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (Online) |
| Volume | 7 |
| Pages (from-to) | 98-110 |
| ISSN | 1939-0041 |
| DOIs | |
| Publication status | Published - 2015 |
| Externally published | Yes |