Abstract
In eutherian mammals, sexual development hinges on the differentiation of the gonadal primordia into either testes or ovaries, in turn determined by the activity of the Y-linked gene Sry. Organogenesis of the gonads requires input from a complex network of morphogenetic signals, many of which are still uncharacterised. Homeobox genes are known to play important roles in embryo morphogenesis and organogenesis in a number of systems. Here, we review current data relating to possible roles of the extended homeobox gene family on gonad development, sex-specific morphogenesis and gametogenesis, and speculate that these genes may play a broader role in these processes than is currently suspected. Copyright (C) 2007 S. Karger AG, Basel.
| Original language | English |
|---|---|
| Journal | Sexual Development |
| Volume | 1 |
| Issue number | 1 |
| Pages (from-to) | 12-23 |
| Number of pages | 12 |
| ISSN | 1661-5425 |
| DOIs | |
| Publication status | Published - 2007 |
| Externally published | Yes |
Keywords
- Animals
- Gametogenesis
- Genes, Homeobox
- Gonads
- Humans
- Mammals
- Sex Differentiation
- Sexual Development
- homeodomain protein
- homeodomain protein Arx
- homeodomain protein Emx2
- homeodomain protein Eso 1
- homeodomain protein Esx1
- homeodomain protein Hox
- homeodomain protein Hoxa11
- homeodomain protein Hoxa13
- homeodomain protein Hoxa7
- homeodomain protein Irx3
- homeodomain protein Lbx2
- homeodomain protein Lhx1
- homeodomain protein Lhx8
- homeodomain protein Lhx9
- homeodomain protein Mkx
- homeodomain protein Nobox
- homeodomain protein Obox1
- homeodomain protein Obox6
- homeodomain protein Pbx4
- homeodomain protein Rhox5
- homeodomain protein Rhox6
- homeodomain protein Sprm1
- homeodomain protein TGIF
- LIM protein
- steroidogenic factor 1
- testis determining factor
- transcription factor PBX1
- unclassified drug
- developmental genetics
- developmental stage
- embryo development
- gene function
- gonad development
- human
- mammalian genetics
- morphogenesis
- multigene family
- nonhuman
- organogenesis
- placental mammals
- postnatal development
- priority journal
- review
- sexual development
- spermatogenesis
- SRY gene
- transcription regulation
- Eutheria
- Mammalia
- Gonadogenesis
- Homeobox
- Hox genes
- Rhox genes
- Sex determination
- Sexual development
- DEVELOPMENTAL
- FEMALE REPRODUCTIVE-TRACT
- MALE GERM-CELL
- MOUSE HOMEOBOX
- ONCOFETAL GENE
- EMBRYONIC-DEVELOPMENT
- TRANSCRIPTION FACTORS
- EXPRESSION PATTERNS
- ADRENAL DEVELOPMENT
- ENDOMETRIAL CELLS
- CEREBRAL-CORTEX
- gametogenesis
- gonadogenesis
- homeobox
- sex determination
- embryo morphogenesis
- sex differentiation
- Vertebrata Chordata Animalia (Animals, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals, Vertebrates) - Mammalia [85700] eutherian mammal common
- eutherian mammal Sry gene [Mammalia] Y- linked gene
- homeobox genes
- 03502, Genetics - General
- 03506, Genetics - Animal
- 16504, Reproductive system - Physiology and biochemistry
- 17002, Endocrine - General
- 25502, Development and Embryology - General and descriptive
- Biochemistry and Molecular Biophysics
- Reproduction
- gonadal primordia reproductive system, endocrine system
- ovary reproductive system
- testis reproductive system
- Development
- Molecular Genetics
- Reproductive System