Involvement of homeobox genes in mammalian sexual development

Terje Svingen, P. Koopman

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In eutherian mammals, sexual development hinges on the differentiation of the gonadal primordia into either testes or ovaries, in turn determined by the activity of the Y-linked gene Sry. Organogenesis of the gonads requires input from a complex network of morphogenetic signals, many of which are still uncharacterised. Homeobox genes are known to play important roles in embryo morphogenesis and organogenesis in a number of systems. Here, we review current data relating to possible roles of the extended homeobox gene family on gonad development, sex-specific morphogenesis and gametogenesis, and speculate that these genes may play a broader role in these processes than is currently suspected. Copyright (C) 2007 S. Karger AG, Basel.
Original languageEnglish
JournalSexual Development
Volume1
Issue number1
Pages (from-to)12-23
Number of pages12
ISSN1661-5425
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Animals
  • Gametogenesis
  • Genes, Homeobox
  • Gonads
  • Humans
  • Mammals
  • Sex Differentiation
  • Sexual Development
  • homeodomain protein
  • homeodomain protein Arx
  • homeodomain protein Emx2
  • homeodomain protein Eso 1
  • homeodomain protein Esx1
  • homeodomain protein Hox
  • homeodomain protein Hoxa11
  • homeodomain protein Hoxa13
  • homeodomain protein Hoxa7
  • homeodomain protein Irx3
  • homeodomain protein Lbx2
  • homeodomain protein Lhx1
  • homeodomain protein Lhx8
  • homeodomain protein Lhx9
  • homeodomain protein Mkx
  • homeodomain protein Nobox
  • homeodomain protein Obox1
  • homeodomain protein Obox6
  • homeodomain protein Pbx4
  • homeodomain protein Rhox5
  • homeodomain protein Rhox6
  • homeodomain protein Sprm1
  • homeodomain protein TGIF
  • LIM protein
  • steroidogenic factor 1
  • testis determining factor
  • transcription factor PBX1
  • unclassified drug
  • developmental genetics
  • developmental stage
  • embryo development
  • gene function
  • gonad development
  • human
  • mammalian genetics
  • morphogenesis
  • multigene family
  • nonhuman
  • organogenesis
  • placental mammals
  • postnatal development
  • priority journal
  • review
  • sexual development
  • spermatogenesis
  • SRY gene
  • transcription regulation
  • Eutheria
  • Mammalia
  • Gonadogenesis
  • Homeobox
  • Hox genes
  • Rhox genes
  • Sex determination
  • Sexual development
  • DEVELOPMENTAL
  • FEMALE REPRODUCTIVE-TRACT
  • MALE GERM-CELL
  • MOUSE HOMEOBOX
  • ONCOFETAL GENE
  • EMBRYONIC-DEVELOPMENT
  • TRANSCRIPTION FACTORS
  • EXPRESSION PATTERNS
  • ADRENAL DEVELOPMENT
  • ENDOMETRIAL CELLS
  • CEREBRAL-CORTEX
  • gametogenesis
  • gonadogenesis
  • homeobox
  • sex determination
  • embryo morphogenesis
  • sex differentiation
  • Vertebrata Chordata Animalia (Animals, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals, Vertebrates) - Mammalia [85700] eutherian mammal common
  • eutherian mammal Sry gene [Mammalia] Y- linked gene
  • homeobox genes
  • 03502, Genetics - General
  • 03506, Genetics - Animal
  • 16504, Reproductive system - Physiology and biochemistry
  • 17002, Endocrine - General
  • 25502, Development and Embryology - General and descriptive
  • Biochemistry and Molecular Biophysics
  • Reproduction
  • gonadal primordia reproductive system, endocrine system
  • ovary reproductive system
  • testis reproductive system
  • Development
  • Molecular Genetics
  • Reproductive System

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