Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia

Research output: Contribution to journalJournal article – Annual report year: 2004Researchpeer-review

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Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia. / Gavier-Widen, Dolores; Brojer, Caroline; Dietz, Hans Henrik; Englund, Lena; Hammer, Anne Sofie; Hedlund, Kjell-Olof; af Segerstad, Carl Hard; Nilsson, Kristina; Nowotny, Norbert; Puurula, Vuokko; Thoren, Peter; Uhlhorn, Henrik; Weissenbock, Herbert; Agren, Erik; Klingeborn, Berndt.

In: Journal of Veterinary Diagnostic Investigation, Vol. 16, No. 4, 2004, p. 305-312.

Research output: Contribution to journalJournal article – Annual report year: 2004Researchpeer-review

Harvard

Gavier-Widen, D, Brojer, C, Dietz, HH, Englund, L, Hammer, AS, Hedlund, K-O, af Segerstad, CH, Nilsson, K, Nowotny, N, Puurula, V, Thoren, P, Uhlhorn, H, Weissenbock, H, Agren, E & Klingeborn, B 2004, 'Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia', Journal of Veterinary Diagnostic Investigation, vol. 16, no. 4, pp. 305-312.

APA

CBE

Gavier-Widen D, Brojer C, Dietz HH, Englund L, Hammer AS, Hedlund K-O, af Segerstad CH, Nilsson K, Nowotny N, Puurula V, Thoren P, Uhlhorn H, Weissenbock H, Agren E, Klingeborn B. 2004. Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia. Journal of Veterinary Diagnostic Investigation. 16(4):305-312.

MLA

Vancouver

Author

Gavier-Widen, Dolores ; Brojer, Caroline ; Dietz, Hans Henrik ; Englund, Lena ; Hammer, Anne Sofie ; Hedlund, Kjell-Olof ; af Segerstad, Carl Hard ; Nilsson, Kristina ; Nowotny, Norbert ; Puurula, Vuokko ; Thoren, Peter ; Uhlhorn, Henrik ; Weissenbock, Herbert ; Agren, Erik ; Klingeborn, Berndt. / Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia. In: Journal of Veterinary Diagnostic Investigation. 2004 ; Vol. 16, No. 4. pp. 305-312.

Bibtex

@article{9d95b2d0d4e944b794427b08d2505aed,
title = "Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia",
abstract = "An apparently novel neurological disease clinically characterized by shaking, tremors, seizures, staggering gait, and ataxia was first observed in farmed mink kits in Denmark in 2000 and subsequently in Sweden, Denmark, and Finland in 2001, and again in Denmark in 2002. Lymphoplasmacytic encephalomyelitis was found in the affected kits. The lesions were most severe in the brainstem and cerebellum and consisted of neuronal degeneration and necrosis, neuronophagia, focal and diffuse gliosis, perivascular cuffs formed by lymphocytes, plasma cells and macrophages, and segmental loss of Purkinje cells. Testing was conducted to determine the cause of the disease, including general virological investigations (virus culture, negative-staining electron microscopy, immunoelectron microscopy, polymerase chain reaction for herpesviruses, adenoviruses, pestiviruses, and coronaviruses), tests for specific viral diseases (canine distemper, Borna disease, Louping ill, West Nile virus infection, tick-borne encephalitis, Aleutian disease), tests for protozoa (Toxoplasma gondii, Neospora caninum, Encephalitozoon cuniculi), bacteria (general culture, listeria, Clamydophila psittaci), and intracerebral inoculation of neonatal mice. The results of all these investigations were negative. One group of 3 mink kits inoculated intracerebrally with brain homogenate of affected mink developed clinical signs and histological lesions similar to those observed in naturally infected mink. Based on the histopathological features, it is postulated that the disease is caused by a yet unidentified virus.",
author = "Dolores Gavier-Widen and Caroline Brojer and Dietz, {Hans Henrik} and Lena Englund and Hammer, {Anne Sofie} and Kjell-Olof Hedlund and {af Segerstad}, {Carl Hard} and Kristina Nilsson and Norbert Nowotny and Vuokko Puurula and Peter Thoren and Henrik Uhlhorn and Herbert Weissenbock and Erik Agren and Berndt Klingeborn",
year = "2004",
language = "English",
volume = "16",
pages = "305--312",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "Sage Publications, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Investigations into shaking mink syndrome: an encephalomyelitis of unknown cause in farmed mink (Mustela vison) kits in Scandinavia

AU - Gavier-Widen, Dolores

AU - Brojer, Caroline

AU - Dietz, Hans Henrik

AU - Englund, Lena

AU - Hammer, Anne Sofie

AU - Hedlund, Kjell-Olof

AU - af Segerstad, Carl Hard

AU - Nilsson, Kristina

AU - Nowotny, Norbert

AU - Puurula, Vuokko

AU - Thoren, Peter

AU - Uhlhorn, Henrik

AU - Weissenbock, Herbert

AU - Agren, Erik

AU - Klingeborn, Berndt

PY - 2004

Y1 - 2004

N2 - An apparently novel neurological disease clinically characterized by shaking, tremors, seizures, staggering gait, and ataxia was first observed in farmed mink kits in Denmark in 2000 and subsequently in Sweden, Denmark, and Finland in 2001, and again in Denmark in 2002. Lymphoplasmacytic encephalomyelitis was found in the affected kits. The lesions were most severe in the brainstem and cerebellum and consisted of neuronal degeneration and necrosis, neuronophagia, focal and diffuse gliosis, perivascular cuffs formed by lymphocytes, plasma cells and macrophages, and segmental loss of Purkinje cells. Testing was conducted to determine the cause of the disease, including general virological investigations (virus culture, negative-staining electron microscopy, immunoelectron microscopy, polymerase chain reaction for herpesviruses, adenoviruses, pestiviruses, and coronaviruses), tests for specific viral diseases (canine distemper, Borna disease, Louping ill, West Nile virus infection, tick-borne encephalitis, Aleutian disease), tests for protozoa (Toxoplasma gondii, Neospora caninum, Encephalitozoon cuniculi), bacteria (general culture, listeria, Clamydophila psittaci), and intracerebral inoculation of neonatal mice. The results of all these investigations were negative. One group of 3 mink kits inoculated intracerebrally with brain homogenate of affected mink developed clinical signs and histological lesions similar to those observed in naturally infected mink. Based on the histopathological features, it is postulated that the disease is caused by a yet unidentified virus.

AB - An apparently novel neurological disease clinically characterized by shaking, tremors, seizures, staggering gait, and ataxia was first observed in farmed mink kits in Denmark in 2000 and subsequently in Sweden, Denmark, and Finland in 2001, and again in Denmark in 2002. Lymphoplasmacytic encephalomyelitis was found in the affected kits. The lesions were most severe in the brainstem and cerebellum and consisted of neuronal degeneration and necrosis, neuronophagia, focal and diffuse gliosis, perivascular cuffs formed by lymphocytes, plasma cells and macrophages, and segmental loss of Purkinje cells. Testing was conducted to determine the cause of the disease, including general virological investigations (virus culture, negative-staining electron microscopy, immunoelectron microscopy, polymerase chain reaction for herpesviruses, adenoviruses, pestiviruses, and coronaviruses), tests for specific viral diseases (canine distemper, Borna disease, Louping ill, West Nile virus infection, tick-borne encephalitis, Aleutian disease), tests for protozoa (Toxoplasma gondii, Neospora caninum, Encephalitozoon cuniculi), bacteria (general culture, listeria, Clamydophila psittaci), and intracerebral inoculation of neonatal mice. The results of all these investigations were negative. One group of 3 mink kits inoculated intracerebrally with brain homogenate of affected mink developed clinical signs and histological lesions similar to those observed in naturally infected mink. Based on the histopathological features, it is postulated that the disease is caused by a yet unidentified virus.

M3 - Journal article

VL - 16

SP - 305

EP - 312

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 4

ER -