Investigation of the Thermostability of Bovine Submaxillary Mucin (BSM) and its Impact on Lubrication

Jan Busk Madsen; Kirsi I. Pakkanen; Seunghwan Lee; Yang Dan

doi:10.1016/j.apcbee.2013.08.006

Investigation of the Thermostability of Bovine Submaxillary Mucin (BSM) and its Impact on Lubrication

Jan Busk Madsen, Kirsi I. Pakkanen, Seunghwan Lee, Yang Dan

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Abstract

Bovine Submaxillary Mucin (BSM) generates thin film layers via spontaneous adsorption onto hydrophobic surfaces such as Poly(dimethylsiloxane) (PDMS) and High Density Polyethylene (HDPE). A characteristic feature of mucin is its tribological- or lubricating properties. Circular dichroismspectroscopyrevealed that BSM is thermally stable over a wide range of temperatures (5–85°C) in its conformation, and Pin-on-Disk tribometry at low speeds showed negligible influence on lubricating properties. Employing the Mini Traction Machine, BSM was found to retain comparable lubricating properties after heating to 80°C and subsequent cooling. Random coiled secondary- and lack of tertiary structure in BSM is believed to contribute to the heat tolerance observed with regards to its conformational and lubrication properties.

Original language	English
Journal	A P C B E E Procedia
Volume	7
Pages (from-to)	21-26
ISSN	2212-6708
DOIs	https://doi.org/10.1016/j.apcbee.2013.08.006
Publication status	Published - 2013
Event	3rd International Conference on Biomedical Engineering and Technology (ICBET 2013) - Copenhagen, Denmark Duration: 19 May 2013 → 20 May 2013 Conference number: 3

Conference

Conference	3rd International Conference on Biomedical Engineering and Technology (ICBET 2013)
Number	3
Country/Territory	Denmark
City	Copenhagen
Period	19/05/2013 → 20/05/2013

Bibliographical note

Asia-Pacific Chemical, Biological & Environmental Engineering Society

Keywords

Bovine Submaxillary Mucin
Biolubrication
Surface Coating
Biotribology

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title = "Investigation of the Thermostability of Bovine Submaxillary Mucin (BSM) and its Impact on Lubrication",

abstract = "Bovine Submaxillary Mucin (BSM) generates thin film layers via spontaneous adsorption onto hydrophobic surfaces such as Poly(dimethylsiloxane) (PDMS) and High Density Polyethylene (HDPE). A characteristic feature of mucin is its tribological- or lubricating properties. Circular dichroismspectroscopyrevealed that BSM is thermally stable over a wide range of temperatures (5–85°C) in its conformation, and Pin-on-Disk tribometry at low speeds showed negligible influence on lubricating properties. Employing the Mini Traction Machine, BSM was found to retain comparable lubricating properties after heating to 80°C and subsequent cooling. Random coiled secondary- and lack of tertiary structure in BSM is believed to contribute to the heat tolerance observed with regards to its conformational and lubrication properties.",

keywords = "Bovine Submaxillary Mucin, Biolubrication, Surface Coating, Biotribology",

author = "Madsen, {Jan Busk} and Pakkanen, {Kirsi I.} and Seunghwan Lee and {Yang Dan}",

note = "Asia-Pacific Chemical, Biological & Environmental Engineering Society; 3rd International Conference on Biomedical Engineering and Technology (ICBET 2013), ICBET ; Conference date: 19-05-2013 Through 20-05-2013",

year = "2013",

doi = "10.1016/j.apcbee.2013.08.006",

language = "English",

volume = "7",

pages = "21--26",

journal = "A P C B E E Procedia",

issn = "2212-6708",

publisher = "Elsevier",

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AU - Madsen, Jan Busk

AU - Pakkanen, Kirsi I.

AU - Lee, Seunghwan

AU - Yang Dan,

N1 - Conference code: 3

PY - 2013

Y1 - 2013

N2 - Bovine Submaxillary Mucin (BSM) generates thin film layers via spontaneous adsorption onto hydrophobic surfaces such as Poly(dimethylsiloxane) (PDMS) and High Density Polyethylene (HDPE). A characteristic feature of mucin is its tribological- or lubricating properties. Circular dichroismspectroscopyrevealed that BSM is thermally stable over a wide range of temperatures (5–85°C) in its conformation, and Pin-on-Disk tribometry at low speeds showed negligible influence on lubricating properties. Employing the Mini Traction Machine, BSM was found to retain comparable lubricating properties after heating to 80°C and subsequent cooling. Random coiled secondary- and lack of tertiary structure in BSM is believed to contribute to the heat tolerance observed with regards to its conformational and lubrication properties.

AB - Bovine Submaxillary Mucin (BSM) generates thin film layers via spontaneous adsorption onto hydrophobic surfaces such as Poly(dimethylsiloxane) (PDMS) and High Density Polyethylene (HDPE). A characteristic feature of mucin is its tribological- or lubricating properties. Circular dichroismspectroscopyrevealed that BSM is thermally stable over a wide range of temperatures (5–85°C) in its conformation, and Pin-on-Disk tribometry at low speeds showed negligible influence on lubricating properties. Employing the Mini Traction Machine, BSM was found to retain comparable lubricating properties after heating to 80°C and subsequent cooling. Random coiled secondary- and lack of tertiary structure in BSM is believed to contribute to the heat tolerance observed with regards to its conformational and lubrication properties.

KW - Bovine Submaxillary Mucin

KW - Biolubrication

KW - Surface Coating

KW - Biotribology

U2 - 10.1016/j.apcbee.2013.08.006

DO - 10.1016/j.apcbee.2013.08.006

M3 - Conference article

SN - 2212-6708

VL - 7

SP - 21

EP - 26

JO - A P C B E E Procedia

JF - A P C B E E Procedia

T2 - 3rd International Conference on Biomedical Engineering and Technology (ICBET 2013)

Y2 - 19 May 2013 through 20 May 2013

ER -

Investigation of the Thermostability of Bovine Submaxillary Mucin (BSM) and its Impact on Lubrication

Abstract

Conference

Bibliographical note

Keywords

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