Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

Zarmeena Abid*, Mette Dalskov Mosgaard, Giorgio Manfroni, Ritika Singh Petersen, Line Hagner Nielsen, Anette Müllertz, Anja Boisen, Stephan Sylvest Keller

*Corresponding author for this work

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Abstract

Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks.
Original languageEnglish
Article number1828
JournalPolymers
Volume11
Number of pages10
ISSN2073-4360
DOIs
Publication statusPublished - 2019

Keywords

  • Hot punching
  • Embossing
  • Drug delivery
  • Biodegradable polymers
  • Thin films
  • Microdevices
  • Mucoadhesion
  • Biodegradation

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