TY - JOUR
T1 - Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
AU - Abid, Zarmeena
AU - Mosgaard, Mette Dalskov
AU - Manfroni, Giorgio
AU - Petersen, Ritika Singh
AU - Nielsen, Line Hagner
AU - Müllertz, Anette
AU - Boisen, Anja
AU - Keller, Stephan Sylvest
PY - 2019
Y1 - 2019
N2 - Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks.
AB - Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks.
KW - Hot punching
KW - Embossing
KW - Drug delivery
KW - Biodegradable polymers
KW - Thin films
KW - Microdevices
KW - Mucoadhesion
KW - Biodegradation
U2 - 10.3390/polym11111828
DO - 10.3390/polym11111828
M3 - Journal article
C2 - 31703261
SN - 2073-4360
VL - 11
JO - Polymers
JF - Polymers
M1 - 1828
ER -