Abstract
Boar taint (BT) is an offensive flavor in non-castrated male pigs. However, studies of genome-wide DNA methylation profiles on all reference sequence genes to reveal epigenetic information associated with BT was scarce. Reduced representation bisulfite sequencing (RRBS) is an efficient technology to identify candidate epigenetic biomarkers associated with BT. Three different BT levels were analyzed using RRBS data to calculate differentially methylated genes (DMGs). In this study, we found 411
21 DMGs (Q-value < 0.01) out of 4566 reference genes. Hyper-methylation DMGs were revealed to be mainly enriched in five significant pathways (qvalue < 0.05). These results could contribute to the understanding of methylation levels on reference sequence genes in pigs and the usage of genomic selection for low BT in the breeding programs.
| Original language | English |
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| Title of host publication | Proceedings of 27th International Symposium of Animal Science Days |
| Publication date | 2019 |
| Publication status | Published - 2019 |
| Event | 27th International Symposium of Animal Science Days - Prague, Czech Republic Duration: 18 Sept 2019 → 20 Sept 2019 Conference number: 27 |
Conference
| Conference | 27th International Symposium of Animal Science Days |
|---|---|
| Number | 27 |
| Country/Territory | Czech Republic |
| City | Prague |
| Period | 18/09/2019 → 20/09/2019 |
Keywords
- Boar taint
- DNA methylation
- Reduced representation bisulfite sequencing
- Differentially methylated genes