Investigation of dna methylation on porcine reference sequence genes for boar taint trait

Xiao Wang, Haja Kadarmideen

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Abstract

Boar taint (BT) is an offensive flavor in non-castrated male pigs. However, studies of genome-wide DNA methylation profiles on all reference sequence genes to reveal epigenetic information associated with BT was scarce. Reduced representation bisulfite sequencing (RRBS) is an efficient technology to identify candidate epigenetic biomarkers associated with BT. Three different BT levels were analyzed using RRBS data to calculate differentially methylated genes (DMGs). In this study, we found 411 21 DMGs (Q-value < 0.01) out of 4566 reference genes. Hyper-methylation DMGs were revealed to be mainly enriched in five significant pathways (qvalue < 0.05). These results could contribute to the understanding of methylation levels on reference sequence genes in pigs and the usage of genomic selection for low BT in the breeding programs.
Original languageEnglish
Title of host publicationProceedings of 27th International Symposium of Animal Science Days
Publication date2019
Publication statusPublished - 2019
Event27th International Symposium of Animal Science Days - Prague, Czech Republic
Duration: 18 Sep 201920 Sep 2019

Conference

Conference27th International Symposium of Animal Science Days
Country/TerritoryCzech Republic
CityPrague
Period18/09/201920/09/2019

Keywords

  • Boar taint
  • DNA methylation
  • Reduced representation bisulfite sequencing
  • Differentially methylated genes

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