Investigation of cleaning and regeneration methods for reliable construction of DNA cantilever biosensors

Xueling Quan, Sun Yi, Arto Heiskanen, Anders Wolff, Peter Grutter, Anja Boisen

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    Abstract

    Biosensing systems based on detecting changes in cantilever surface stress have attracted great interest. To achieve high reliability of measurements, high quality and high reproducibility in functionalization of the sensor surface are key points. In this paper, we investigate different methods to clean and regenerate the sensing surface of cantilever biosensors. Perchloric acid potential sweep, potassium hydroxide-hydrogen peroxide, and piranha cleaning are investigated here. Peak-current potential differences from cyclic voltammetry, X-ray photo-electron spectroscopy and fluorescence detection are applied to characterize surface cleanliness. The experimental results show that piranha cleaning is the most reliable and efficient cleaning procedure.
    Original languageEnglish
    Publication date2012
    Number of pages2
    Publication statusPublished - 2012
    Event9th International Nanomechanical Sensing Workshop - IIT Bombay, Mumbai, India
    Duration: 6 Jun 20128 Jun 2012

    Workshop

    Workshop9th International Nanomechanical Sensing Workshop
    LocationIIT Bombay
    Country/TerritoryIndia
    CityMumbai
    Period06/06/201208/06/2012

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