Intraoperative Detection and Eradication of Residual Microtumors with Gap-Enhanced Raman Tags

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review


  • Author: Qiu, Yuanyuan

    Shanghai Jiao Tong University, China

  • Author: Zhang, Yuqing

    Shanghai Jiao Tong University, China

  • Author: Li, Mingwang

    Shanghai Jiao Tong University

  • Author: Chen, Gaoxian

    Shanghai Jiao Tong University, China

  • Author: Fan, Chenchen

    Shanghai Jiao Tong University, China

  • Author: Cui, Kai

    Shanghai Jiao Tong University, China

  • Author: Wan, Jian-Bo

    University of Macau, China

  • Author: Han, Anpan

    Center for Electron Nanoscopy, Technical University of Denmark, Fysikvej, 2800, Kgs. Lyngby, Denmark

  • Author: Ye, Jian

    Shanghai Jiao Tong University, China

  • Author: Xiao, Zeyu

    Shanghai Jiao Tong University, China

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The inability to intraoperatively diagnose and eliminate microscopic residual tumors represents a significant challenge in cancer surgery. These residual microtumors cause lethal recurrence and metastasis. Herein, we show a crucial example of Raman imaging with gap-enhanced Raman tags (GERTs) to serve as a robust platform for intraoperative detection and eradication of residual microscopic foci, which exist in surgical margins, tumor invasion, and multifocal tumor spread. The GERTs feature gap-enhanced gold core-shell nanostructures, with Raman reporters embedding inside the interior gap junction. This nanostructure elicits highly sensitive and photostable Raman signals for microtumor detection by applying a 785 nm, low-energy laser and produces hyperthermia effects for microtumor ablation upon switching a 808 nm, high-power laser. In the orthotopic prostate metastasis tumor model, systematic delivery of GERTs enabled precise imaging and real-time ablation of macroscopic malignant lesions around the surgical bed without damaging normal tissues. Consequently, the GERTs-based surgery prevented local recurrence and delivered 100% tumor-free survival. These results suggest the efficiency of theranostic GERTs for precise detection and removal of residual miroctumors, broadening the avenues to apply Raman-based imaging for theranostic precision medicine.
Original languageEnglish
JournalACS Nano
Issue number8
Pages (from-to)7974-7985
Publication statusPublished - 2018
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Nanomedicine, Gap-enhanced Raman tag, Cancer theranostics, Residual microtumors, Surface-enhanced Raman spectroscopy

ID: 156608854