Intramyocellular triglyceride content in man, influence of sex, obesity and glycaemic control

Steen B Haugaard, Huiling Mu, Allan Vaag, Sten Madsbad

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    It remains unknown whether sex impacts on intramyocellular triglyceride (IMTG) in obesity. as has been shown in non-obese subjects, and if so, whether this may have implications on the association between IMTG and insulin sensitivity. Subject and methods: A Muscle biopsy from vastus lateralis was obtained in 2 7 obese women (body mass index (BMI) = 35.5 +/- 0.8 kg/m(2) ; mean +/- S.E.M., percentage of body fat (PBF) = 44 +/- 1, n = 7 impaired fasting glucose. n = 7 type 2 diabetes), 20 obese men (BMI = 35.8 +/- 0.8 kg/m(2): PBF = 33 +/- 1, n = 4 impaired-fasting-glucose; n = 6 type 2 diabetes) and 12 lean sedentary healthy individuals (controls: n = 7 women, BMI = 21.8 +/- 0.7 kg/m(2), PBF = 20 +/- 2: n = 5 men, BMI = 23.6 +/- 0.5 kg/m(2). PBF = 13 +/- 2). IMTG was determined by chromatography. Results: IMTG wits increased twofold in obese women compared to obese men, lean men and lean women respectively (21.9 +/- 2.4 mg/g wet weight, 10.9 +/- 1.5. 9.8 +/- 2.1 and 10.9 +/- 2.4 mg/g. P
    Original languageEnglish
    JournalEuropean Journal of Endocrinology
    Volume161
    Issue number1
    Pages (from-to)57-64
    ISSN0804-4643
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Dive into the research topics of 'Intramyocellular triglyceride content in man, influence of sex, obesity and glycaemic control'. Together they form a unique fingerprint.

    Cite this