Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis

Lotte K. Vogel; Mona Saebo; Helle Hoyer; Tine Iskov Kopp; Ulla  Vogel; Sine Godiksen; Franz B. Frenzel; Julian Hamfjord; Inger Marie Bowitz-Lothe; Egil Johnson; Elin H. Kure; Vibeke Andersen

doi:10.1371/journal.pone.0105254

Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis

Lotte K. Vogel
, Mona Saebo
, Helle Hoyer
, Tine Iskov Kopp
, Ulla Vogel
, Sine Godiksen
, Franz B. Frenzel
, Julian Hamfjord
, Inger Marie Bowitz-Lothe
, Egil Johnson
, Elin H. Kure
, Vibeke Andersen

National Food Institute

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Background & Aims: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. Methods: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. Results: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P

Original language	English
Article number	e105254
Journal	PLOS ONE
Volume	9
Issue number	8
Number of pages	8
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0105254
Publication status	Published - 2014

Keywords

MULTIDISCIPLINARY
INFLAMMATORY-BOWEL-DISEASE
CYCLOOXYGENASE-2 EXPRESSION
RISK-FACTORS
NSAID USE
CANCER
ADENOMAS
CARCINOMAS
COX-2
CHEMOPREVENTION
METAANALYSIS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148233/

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title = "Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis",

abstract = "Background \& Aims: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. Methods: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. Results: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P",

keywords = "MULTIDISCIPLINARY, INFLAMMATORY-BOWEL-DISEASE, CYCLOOXYGENASE-2 EXPRESSION, RISK-FACTORS, NSAID USE, CANCER, ADENOMAS, CARCINOMAS, COX-2, CHEMOPREVENTION, METAANALYSIS",

author = "Vogel, \{Lotte K.\} and Mona Saebo and Helle Hoyer and Kopp, \{Tine Iskov\} and Ulla Vogel and Sine Godiksen and Frenzel, \{Franz B.\} and Julian Hamfjord and Bowitz-Lothe, \{Inger Marie\} and Egil Johnson and Kure, \{Elin H.\} and Vibeke Andersen",

year = "2014",

doi = "10.1371/journal.pone.0105254",

language = "English",

volume = "9",

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T1 - Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis

AU - Vogel, Lotte K.

AU - Saebo, Mona

AU - Hoyer, Helle

AU - Kopp, Tine Iskov

AU - Vogel, Ulla

AU - Godiksen, Sine

AU - Frenzel, Franz B.

AU - Hamfjord, Julian

AU - Bowitz-Lothe, Inger Marie

AU - Johnson, Egil

AU - Kure, Elin H.

AU - Andersen, Vibeke

PY - 2014

Y1 - 2014

N2 - Background & Aims: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. Methods: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. Results: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P

AB - Background & Aims: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. Methods: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. Results: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P

KW - MULTIDISCIPLINARY

KW - INFLAMMATORY-BOWEL-DISEASE

KW - CYCLOOXYGENASE-2 EXPRESSION

KW - RISK-FACTORS

KW - NSAID USE

KW - CANCER

KW - ADENOMAS

KW - CARCINOMAS

KW - COX-2

KW - CHEMOPREVENTION

KW - METAANALYSIS

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DO - 10.1371/journal.pone.0105254

M3 - Journal article

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JF - PLOS ONE

IS - 8

M1 - e105254

ER -

Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis

Abstract

Keywords

UN SDGs

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