Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis

Lotte K. Vogel, Mona Saebo, Helle Hoyer, Tine Iskov Kopp, Ulla Vogel, Sine Godiksen, Franz B. Frenzel, Julian Hamfjord, Inger Marie Bowitz-Lothe, Egil Johnson, Elin H. Kure, Vibeke Andersen

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Abstract

Background & Aims: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. Methods: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. Results: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P
Original languageEnglish
Article numbere105254
JournalPLOS ONE
Volume9
Issue number8
Number of pages8
ISSN1932-6203
DOIs
Publication statusPublished - 2014

Keywords

  • MULTIDISCIPLINARY
  • INFLAMMATORY-BOWEL-DISEASE
  • CYCLOOXYGENASE-2 EXPRESSION
  • RISK-FACTORS
  • NSAID USE
  • CANCER
  • ADENOMAS
  • CARCINOMAS
  • COX-2
  • CHEMOPREVENTION
  • METAANALYSIS

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