Intestinal Enterococcus abundance correlates with excessive weight gain and increased plasma leptin in breastfed infants

Martin Frederik Laursen, Melanie Wange Larsson, Mads Vendelbo Lind, Anni Larnkjær, Christian Mølgaard, Kim F Michaelsen, Martin Iain Bahl, Tine Rask Licht*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

55 Downloads (Pure)


Epidemiological evidence indicates that breastfeeding provides protection against development of overweight/obesity. Nonetheless, a small subgroup of infants undergo excessive weight gain during exclusive breastfeeding, a phenomenon that remains unexplained. Breastmilk contains both gut-seeding microbes and substrates for microbial growth in the gut of infants, and a large body of evidence suggests a role for gut microbes in host metabolism. Based on the recently established SKOT III cohort, we investigated the role of the infant gut microbiota in excessive infant weight gain during breastfeeding, including 30 exclusively breastfed infants, 13 of which exhibited excessive weight gain and 17 controls which exhibited normal weight gain during infancy. Infants undergoing excessive weight gain during breastfeeding had a reduced abundance of gut Enterococcus as compared with that observed in the controls. Within the complete cohort, Enterococcus abundance correlated inversely with age/gender-adjusted body-weight, body-mass index and waist circumference, body fat and levels of plasma leptin. The reduced abundance of Enterococcus in infants with excessive weight gain was coupled to a lower content of Enterococcus in breast milk samples of their mothers than seen for mothers in the control group. Together, this suggests that lack of breast milk-derived gut-seeding Enterococci may contribute to excessive weight gain in breastfed infants.
Original languageEnglish
Article numberfiaa066
JournalFEMS Microbiology Ecology
Issue number5
Publication statusPublished - 2020

Fingerprint Dive into the research topics of 'Intestinal Enterococcus abundance correlates with excessive weight gain and increased plasma leptin in breastfed infants'. Together they form a unique fingerprint.

Cite this