Interplay between food and gut microbiota in health and disease

Niels Banhos Danneskiold-Samsøe, Helena Dias de Freitas Queiroz Barros, Rosangela Santos, Juliano Lemos Bicas, Cinthia Baú Betim Cazarin, Lise Madsen, Karsten Kristiansen*, Glaucia Maria Pastore, Susanne Brix, Mario Roberto Marostica Junior

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

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Abstract

Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in relation to digestion and absorption of dietary components. They biotransform food components and produce metabolites, which in combination with food components shape and modulate the host immune system and metabolic responses. Reciprocally, the diet modulates the composition and functional capacity of the gut microbiota, which subsequently influence host biochemical processes establishing a system of mutual interaction and inter-dependency. Macronutrients, fibers, as well as polyphenols and prebiotics are strong drivers shaping the composition of the gut microbiota. Especially, short-chain fatty acids produced from ingested fibers and tryptophan metabolites are key in modulating host immune responses. Since reciprocal interactions between diet, host, and microbiota are personal, understanding this complex network of interactions calls for novel use of large datasets and the implementation of machine learning algorithms and artificial intelligence. In this review, we aim to provide a base for future investigations of how interactions between food components and gut microbiota may influence or even determine human health and disease.
Original languageEnglish
JournalFood Research International
Volume115
Pages (from-to)23-31
ISSN0963-9969
DOIs
Publication statusPublished - 2019

Keywords

  • Gut microbiota
  • Macronutrients
  • Polyphenols
  • Prebiotics
  • Health
  • Disease

Cite this

Danneskiold-Samsøe, N. B., de Freitas Queiroz Barros, H. D., Santos, R., Bicas, J. L., Cazarin, C. B. B., Madsen, L., ... Junior, M. R. M. (2019). Interplay between food and gut microbiota in health and disease. Food Research International, 115, 23-31. https://doi.org/10.1016/j.foodres.2018.07.043
Danneskiold-Samsøe, Niels Banhos ; de Freitas Queiroz Barros, Helena Dias ; Santos, Rosangela ; Bicas, Juliano Lemos ; Cazarin, Cinthia Baú Betim ; Madsen, Lise ; Kristiansen, Karsten ; Pastore, Glaucia Maria ; Brix, Susanne ; Junior, Mario Roberto Marostica. / Interplay between food and gut microbiota in health and disease. In: Food Research International. 2019 ; Vol. 115. pp. 23-31.
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title = "Interplay between food and gut microbiota in health and disease",
abstract = "Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in relation to digestion and absorption of dietary components. They biotransform food components and produce metabolites, which in combination with food components shape and modulate the host immune system and metabolic responses. Reciprocally, the diet modulates the composition and functional capacity of the gut microbiota, which subsequently influence host biochemical processes establishing a system of mutual interaction and inter-dependency. Macronutrients, fibers, as well as polyphenols and prebiotics are strong drivers shaping the composition of the gut microbiota. Especially, short-chain fatty acids produced from ingested fibers and tryptophan metabolites are key in modulating host immune responses. Since reciprocal interactions between diet, host, and microbiota are personal, understanding this complex network of interactions calls for novel use of large datasets and the implementation of machine learning algorithms and artificial intelligence. In this review, we aim to provide a base for future investigations of how interactions between food components and gut microbiota may influence or even determine human health and disease.",
keywords = "Gut microbiota, Macronutrients, Polyphenols, Prebiotics, Health, Disease",
author = "Danneskiold-Sams{\o}e, {Niels Banhos} and {de Freitas Queiroz Barros}, {Helena Dias} and Rosangela Santos and Bicas, {Juliano Lemos} and Cazarin, {Cinthia Ba{\'u} Betim} and Lise Madsen and Karsten Kristiansen and Pastore, {Glaucia Maria} and Susanne Brix and Junior, {Mario Roberto Marostica}",
year = "2019",
doi = "10.1016/j.foodres.2018.07.043",
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Danneskiold-Samsøe, NB, de Freitas Queiroz Barros, HD, Santos, R, Bicas, JL, Cazarin, CBB, Madsen, L, Kristiansen, K, Pastore, GM, Brix, S & Junior, MRM 2019, 'Interplay between food and gut microbiota in health and disease', Food Research International, vol. 115, pp. 23-31. https://doi.org/10.1016/j.foodres.2018.07.043

Interplay between food and gut microbiota in health and disease. / Danneskiold-Samsøe, Niels Banhos; de Freitas Queiroz Barros, Helena Dias; Santos, Rosangela; Bicas, Juliano Lemos; Cazarin, Cinthia Baú Betim; Madsen, Lise; Kristiansen, Karsten; Pastore, Glaucia Maria; Brix, Susanne; Junior, Mario Roberto Marostica.

In: Food Research International, Vol. 115, 2019, p. 23-31.

Research output: Contribution to journalReviewResearchpeer-review

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AU - Danneskiold-Samsøe, Niels Banhos

AU - de Freitas Queiroz Barros, Helena Dias

AU - Santos, Rosangela

AU - Bicas, Juliano Lemos

AU - Cazarin, Cinthia Baú Betim

AU - Madsen, Lise

AU - Kristiansen, Karsten

AU - Pastore, Glaucia Maria

AU - Brix, Susanne

AU - Junior, Mario Roberto Marostica

PY - 2019

Y1 - 2019

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AB - Numerous microorganisms colonize the human gastrointestinal tract playing pivotal roles in relation to digestion and absorption of dietary components. They biotransform food components and produce metabolites, which in combination with food components shape and modulate the host immune system and metabolic responses. Reciprocally, the diet modulates the composition and functional capacity of the gut microbiota, which subsequently influence host biochemical processes establishing a system of mutual interaction and inter-dependency. Macronutrients, fibers, as well as polyphenols and prebiotics are strong drivers shaping the composition of the gut microbiota. Especially, short-chain fatty acids produced from ingested fibers and tryptophan metabolites are key in modulating host immune responses. Since reciprocal interactions between diet, host, and microbiota are personal, understanding this complex network of interactions calls for novel use of large datasets and the implementation of machine learning algorithms and artificial intelligence. In this review, we aim to provide a base for future investigations of how interactions between food components and gut microbiota may influence or even determine human health and disease.

KW - Gut microbiota

KW - Macronutrients

KW - Polyphenols

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DO - 10.1016/j.foodres.2018.07.043

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VL - 115

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JO - Food Research International

JF - Food Research International

SN - 0963-9969

ER -

Danneskiold-Samsøe NB, de Freitas Queiroz Barros HD, Santos R, Bicas JL, Cazarin CBB, Madsen L et al. Interplay between food and gut microbiota in health and disease. Food Research International. 2019;115:23-31. https://doi.org/10.1016/j.foodres.2018.07.043