International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

Research output: Contribution to journalJournal article – Annual report year: 2015Researchpeer-review

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International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. / Bal-Price, Anna; Crofton, Kevin M.; Leist, Marcel; Allen, Sandra; Arand, Michael; Buetler, Timo; Delrue, Nathalie; FitzGerald, Rex E.; Hartung, Thomas; Heinonen, Tuula; Hogberg, Helena; Bennekou, Susanne Hougaard; Lichtensteiger, Walter; Oggier, Daniela; Paparella, Martin; Petersen, Marta Axelstad; Piersma, Aldert; Rached, Eva; Schilter, BenoIt; Schmuck, Gabriele; Stoppini, Luc; Tongiorgi, Enrico; Tiramani, Manuela; Monnet-Tschudi, Florianne; Wilks, Martin F.; Ylikomi, Timo; Fritsche, Ellen.

In: Archives of Toxicology, Vol. 89, No. 2, 2015, p. 269-287.

Research output: Contribution to journalJournal article – Annual report year: 2015Researchpeer-review

Harvard

Bal-Price, A, Crofton, KM, Leist, M, Allen, S, Arand, M, Buetler, T, Delrue, N, FitzGerald, RE, Hartung, T, Heinonen, T, Hogberg, H, Bennekou, SH, Lichtensteiger, W, Oggier, D, Paparella, M, Petersen, MA, Piersma, A, Rached, E, Schilter, B, Schmuck, G, Stoppini, L, Tongiorgi, E, Tiramani, M, Monnet-Tschudi, F, Wilks, MF, Ylikomi, T & Fritsche, E 2015, 'International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes', Archives of Toxicology, vol. 89, no. 2, pp. 269-287. https://doi.org/10.1007/s00204-015-1464-2

APA

CBE

Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, Petersen MA, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Monnet-Tschudi F, Wilks MF, Ylikomi T, Fritsche E. 2015. International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Archives of Toxicology. 89(2):269-287. https://doi.org/10.1007/s00204-015-1464-2

MLA

Vancouver

Author

Bal-Price, Anna ; Crofton, Kevin M. ; Leist, Marcel ; Allen, Sandra ; Arand, Michael ; Buetler, Timo ; Delrue, Nathalie ; FitzGerald, Rex E. ; Hartung, Thomas ; Heinonen, Tuula ; Hogberg, Helena ; Bennekou, Susanne Hougaard ; Lichtensteiger, Walter ; Oggier, Daniela ; Paparella, Martin ; Petersen, Marta Axelstad ; Piersma, Aldert ; Rached, Eva ; Schilter, BenoIt ; Schmuck, Gabriele ; Stoppini, Luc ; Tongiorgi, Enrico ; Tiramani, Manuela ; Monnet-Tschudi, Florianne ; Wilks, Martin F. ; Ylikomi, Timo ; Fritsche, Ellen. / International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. In: Archives of Toxicology. 2015 ; Vol. 89, No. 2. pp. 269-287.

Bibtex

@article{152f41c10a3a416c8262b6a2c54908b8,
title = "International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes",
abstract = "A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a matching of regulatory needs on the one hand and the opportunities provided by new test systems and methods on the other hand. Alignment of academically and industrially driven assay development with regulatory needs in the field of DNT is a core mission of the International STakeholder NETwork (ISTNET) in DNT testing. The first meeting of ISTNET was held in Zurich on 23-24 January 2014 in order to explore the concept of adverse outcome pathway (AOP) to practical DNT testing. AOPs were considered promising tools to promote test systems development according to regulatory needs. Moreover, the AOP concept was identified as an important guiding principle to assemble predictive integrated testing strategies (ITSs) for DNT. The recommendations on a road map towards AOP-based DNT testing is considered a stepwise approach, operating initially with incomplete AOPs for compound grouping, and focussing on key events of neurodevelopment. Next steps to be considered in follow-up activities are the use of case studies to further apply the AOP concept in regulatory DNT testing, making use of AOP intersections (common key events) for economic development of screening assays, and addressing the transition from qualitative descriptions to quantitative network modelling.",
author = "Anna Bal-Price and Crofton, {Kevin M.} and Marcel Leist and Sandra Allen and Michael Arand and Timo Buetler and Nathalie Delrue and FitzGerald, {Rex E.} and Thomas Hartung and Tuula Heinonen and Helena Hogberg and Bennekou, {Susanne Hougaard} and Walter Lichtensteiger and Daniela Oggier and Martin Paparella and Petersen, {Marta Axelstad} and Aldert Piersma and Eva Rached and BenoIt Schilter and Gabriele Schmuck and Luc Stoppini and Enrico Tongiorgi and Manuela Tiramani and Florianne Monnet-Tschudi and Wilks, {Martin F.} and Timo Ylikomi and Ellen Fritsche",
year = "2015",
doi = "10.1007/s00204-015-1464-2",
language = "English",
volume = "89",
pages = "269--287",
journal = "Archives of Toxicology",
issn = "0340-5761",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

AU - Bal-Price, Anna

AU - Crofton, Kevin M.

AU - Leist, Marcel

AU - Allen, Sandra

AU - Arand, Michael

AU - Buetler, Timo

AU - Delrue, Nathalie

AU - FitzGerald, Rex E.

AU - Hartung, Thomas

AU - Heinonen, Tuula

AU - Hogberg, Helena

AU - Bennekou, Susanne Hougaard

AU - Lichtensteiger, Walter

AU - Oggier, Daniela

AU - Paparella, Martin

AU - Petersen, Marta Axelstad

AU - Piersma, Aldert

AU - Rached, Eva

AU - Schilter, BenoIt

AU - Schmuck, Gabriele

AU - Stoppini, Luc

AU - Tongiorgi, Enrico

AU - Tiramani, Manuela

AU - Monnet-Tschudi, Florianne

AU - Wilks, Martin F.

AU - Ylikomi, Timo

AU - Fritsche, Ellen

PY - 2015

Y1 - 2015

N2 - A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a matching of regulatory needs on the one hand and the opportunities provided by new test systems and methods on the other hand. Alignment of academically and industrially driven assay development with regulatory needs in the field of DNT is a core mission of the International STakeholder NETwork (ISTNET) in DNT testing. The first meeting of ISTNET was held in Zurich on 23-24 January 2014 in order to explore the concept of adverse outcome pathway (AOP) to practical DNT testing. AOPs were considered promising tools to promote test systems development according to regulatory needs. Moreover, the AOP concept was identified as an important guiding principle to assemble predictive integrated testing strategies (ITSs) for DNT. The recommendations on a road map towards AOP-based DNT testing is considered a stepwise approach, operating initially with incomplete AOPs for compound grouping, and focussing on key events of neurodevelopment. Next steps to be considered in follow-up activities are the use of case studies to further apply the AOP concept in regulatory DNT testing, making use of AOP intersections (common key events) for economic development of screening assays, and addressing the transition from qualitative descriptions to quantitative network modelling.

AB - A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a matching of regulatory needs on the one hand and the opportunities provided by new test systems and methods on the other hand. Alignment of academically and industrially driven assay development with regulatory needs in the field of DNT is a core mission of the International STakeholder NETwork (ISTNET) in DNT testing. The first meeting of ISTNET was held in Zurich on 23-24 January 2014 in order to explore the concept of adverse outcome pathway (AOP) to practical DNT testing. AOPs were considered promising tools to promote test systems development according to regulatory needs. Moreover, the AOP concept was identified as an important guiding principle to assemble predictive integrated testing strategies (ITSs) for DNT. The recommendations on a road map towards AOP-based DNT testing is considered a stepwise approach, operating initially with incomplete AOPs for compound grouping, and focussing on key events of neurodevelopment. Next steps to be considered in follow-up activities are the use of case studies to further apply the AOP concept in regulatory DNT testing, making use of AOP intersections (common key events) for economic development of screening assays, and addressing the transition from qualitative descriptions to quantitative network modelling.

U2 - 10.1007/s00204-015-1464-2

DO - 10.1007/s00204-015-1464-2

M3 - Journal article

VL - 89

SP - 269

EP - 287

JO - Archives of Toxicology

JF - Archives of Toxicology

SN - 0340-5761

IS - 2

ER -