International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe

Mabel Budia-Silva; Tomislav Kostyanev; Stefany Ayala-Montaño; Jose Bravo-Ferrer Acosta; Maria Garcia-Castillo; Rafael Cantón; Herman Goossens; Jesus Rodriguez-Baño; Hajo Grundmann; Sandra Reuter

doi:10.1038/s41467-024-49349-z

International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe

Mabel Budia-Silva
, Tomislav Kostyanev
, Stefany Ayala-Montaño
, Jose Bravo-Ferrer Acosta
, Maria Garcia-Castillo
, Rafael Cantón
, Herman Goossens
, Jesus Rodriguez-Baño
, Hajo Grundmann
, Sandra Reuter^*

^*Corresponding author for this work

University of Freiburg
Instituto de Salud Carlos III
University of Seville
University of Antwerp

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. bla_KPC-like was the most prevalent carbapenemase-encoding gene (46%), with bla_OXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found bla_KPC-like ST258/512 in Greece, Italy, and Spain, bla_OXA-48 ST101 in Serbia and Romania, bla_NDM ST11 in Greece, and bla_OXA-48-like ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.

Original language	English
Article number	5092
Journal	Nature Communications
Volume	15
Issue number	1
Number of pages	11
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-024-49349-z
Publication status	Published - 2024

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title = "International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe",

abstract = "Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. blaKPC-like was the most prevalent carbapenemase-encoding gene (46\%), with blaOXA-48 present in 39\% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found blaKPC-like ST258/512 in Greece, Italy, and Spain, blaOXA-48 ST101 in Serbia and Romania, blaNDM ST11 in Greece, and blaOXA-48-like ST14 in T{\"u}rkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.",

author = "Mabel Budia-Silva and Tomislav Kostyanev and Stefany Ayala-Monta{\~n}o and \{Bravo-Ferrer Acosta\}, Jose and Maria Garcia-Castillo and Rafael Cant{\'o}n and Herman Goossens and Jesus Rodriguez-Ba{\~n}o and Hajo Grundmann and Sandra Reuter",

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doi = "10.1038/s41467-024-49349-z",

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AU - Budia-Silva, Mabel

AU - Kostyanev, Tomislav

AU - Ayala-Montaño, Stefany

AU - Bravo-Ferrer Acosta, Jose

AU - Garcia-Castillo, Maria

AU - Cantón, Rafael

AU - Goossens, Herman

AU - Rodriguez-Baño, Jesus

AU - Grundmann, Hajo

AU - Reuter, Sandra

PY - 2024

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N2 - Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. blaKPC-like was the most prevalent carbapenemase-encoding gene (46%), with blaOXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found blaKPC-like ST258/512 in Greece, Italy, and Spain, blaOXA-48 ST101 in Serbia and Romania, blaNDM ST11 in Greece, and blaOXA-48-like ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.

AB - Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. blaKPC-like was the most prevalent carbapenemase-encoding gene (46%), with blaOXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found blaKPC-like ST258/512 in Greece, Italy, and Spain, blaOXA-48 ST101 in Serbia and Romania, blaNDM ST11 in Greece, and blaOXA-48-like ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.

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DO - 10.1038/s41467-024-49349-z

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SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

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M1 - 5092

ER -

International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe

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