TY - JOUR
T1 - InterMap3D: predicting and visualizing co-evolving protein residues
AU - Oliveira, Rodrigo Gouveia
AU - Roque, francisco jose sousa simôes almeida
AU - Wernersson, Rasmus
AU - Sicheritz-Pontén, Thomas
AU - Sackett, Peter Wad
AU - Mølgaard, Anne
AU - Pedersen, Anders Gorm
PY - 2009
Y1 - 2009
N2 - InterMap3D predicts co-evolving protein residues and plots them on the 3D protein structure. Starting with a single protein sequence, InterMap3D automatically finds a set of homologous sequences, generates an alignment and fetches the most similar 3D structure from the Protein Data Bank (PDB). It can also accept a user-generated alignment. Based on the alignment, co-evolving residues are then predicted using three different methods: Row and Column Weighing of Mutual Information, Mutual Information/Entropy and Dependency. Finally, InterMap3D generates high-quality images of the protein with the predicted co-evolving residues highlighted.
AB - InterMap3D predicts co-evolving protein residues and plots them on the 3D protein structure. Starting with a single protein sequence, InterMap3D automatically finds a set of homologous sequences, generates an alignment and fetches the most similar 3D structure from the Protein Data Bank (PDB). It can also accept a user-generated alignment. Based on the alignment, co-evolving residues are then predicted using three different methods: Row and Column Weighing of Mutual Information, Mutual Information/Entropy and Dependency. Finally, InterMap3D generates high-quality images of the protein with the predicted co-evolving residues highlighted.
U2 - 10.1093/bioinformatics/btp335
DO - 10.1093/bioinformatics/btp335
M3 - Journal article
C2 - 19528088
SN - 1367-4803
VL - 25
SP - 1963
EP - 1965
JO - Bioinformatics
JF - Bioinformatics
IS - 15
ER -