Interfacial electrochemical electron transfer in biology – Towards the level of the single molecule

Jingdong Zhang, Qijin Chi, Allan Glargaard Hansen, Palle Skovhus Jensen, Princia Salvatore, Jens Ulstrup

Research output: Contribution to journalJournal articleResearchpeer-review


Physical electrochemistry has undergone a remarkable evolution over the last few decades, integrating advanced techniques and theory from solid state and surface physics. Single-crystal electrode surfaces have been a core notion, opening for scanning tunnelling microscopy directly in aqueous electrolyte (in situ STM). Interfacial electrochemistry of metalloproteins is presently going through a similar transition. Electrochemical surfaces with thiol-based promoter molecular monolayers (SAMs) as biomolecular electrochemical environments and the biomolecules themselves have been mapped with unprecedented resolution, opening a new area of single-molecule bioelectrochemistry. We consider first in situ STM of small redox molecules, followed by in situ STM of thiol-based SAMs as molecular views of bioelectrochemical environments. We then address electron transfer metalloproteins, and multi-centre metalloenzymes including applied single-biomolecular perspectives based on metalloprotein/metallic nanoparticle hybrids.
Original languageEnglish
JournalFEBS Letters
Pages (from-to)526-535
Publication statusPublished - 2012


  • Metalloproteins
  • Single-crystal electrode surfaces
  • Scanning tunneling microscopy
  • Protein film voltammetry


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