Abstract
Physical electrochemistry has undergone a remarkable evolution over the last few decades, integrating
advanced techniques and theory from solid state and surface physics. Single-crystal electrode surfaces have been a core notion, opening for scanning tunnelling microscopy directly in aqueous electrolyte (in situ STM). Interfacial electrochemistry of metalloproteins is presently going through a similar transition. Electrochemical surfaces with thiol-based promoter molecular monolayers (SAMs) as biomolecular electrochemical environments and the biomolecules themselves have been mapped with unprecedented resolution, opening a new area of single-molecule bioelectrochemistry.
We consider first in situ STM of small redox molecules, followed by in situ STM of thiol-based SAMs as molecular views of bioelectrochemical environments. We then address electron transfer metalloproteins, and multi-centre metalloenzymes including applied single-biomolecular
perspectives based on metalloprotein/metallic nanoparticle hybrids.
Original language | English |
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Journal | FEBS Letters |
Volume | 586 |
Pages (from-to) | 526-535 |
ISSN | 0014-5793 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Metalloproteins
- Single-crystal electrode surfaces
- Scanning tunneling microscopy
- Protein film voltammetry