Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study.

Vibeke Andersen, René Holst, Tine Iskov Kopp, Anne Tjønneland, Ulla Birgitte Vogel

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Abstract

Genetically determined low COX-2 and high IL-1β activity were associated with increased risk of CRC in this northern Caucasian cohort. Furthermore, interactions were found between IL10, IL1b, and PTGS2 and diet and lifestyle factors in relation to CRC. The present study demonstrates that gene-environment interactions may identify genes and environmental factors involved in colorectal carcinogenesis.
Original languageEnglish
Article numbere78366
JournalPloS one.
Volume8
Issue number10
Number of pages10
ISSN1932-6203
DOIs
Publication statusPublished - 2013

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