Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study.

Vibeke Andersen; René Holst; Tine Iskov Kopp; Anne Tjønneland; Ulla Birgitte Vogel

doi:10.1371/journal.pone.0078366

Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study.

Vibeke Andersen, René Holst, Tine Iskov Kopp, Anne Tjønneland, Ulla Birgitte Vogel

National Food Institute

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Abstract

Genetically determined low COX-2 and high IL-1β activity were associated with increased risk of CRC in this northern Caucasian cohort. Furthermore, interactions were found between IL10, IL1b, and PTGS2 and diet and lifestyle factors in relation to CRC. The present study demonstrates that gene-environment interactions may identify genes and environmental factors involved in colorectal carcinogenesis.

Original language	English
Article number	e78366
Journal	PloS one.
Volume	8
Issue number	10
Number of pages	10
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0078366
Publication status	Published - 2013

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title = "Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study.",

abstract = "Genetically determined low COX-2 and high IL-1β activity were associated with increased risk of CRC in this northern Caucasian cohort. Furthermore, interactions were found between IL10, IL1b, and PTGS2 and diet and lifestyle factors in relation to CRC. The present study demonstrates that gene-environment interactions may identify genes and environmental factors involved in colorectal carcinogenesis.",

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AU - Kopp, Tine Iskov

AU - Tjønneland, Anne

AU - Vogel, Ulla Birgitte

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AB - Genetically determined low COX-2 and high IL-1β activity were associated with increased risk of CRC in this northern Caucasian cohort. Furthermore, interactions were found between IL10, IL1b, and PTGS2 and diet and lifestyle factors in relation to CRC. The present study demonstrates that gene-environment interactions may identify genes and environmental factors involved in colorectal carcinogenesis.

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DO - 10.1371/journal.pone.0078366

M3 - Journal article

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Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study.

Abstract

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