TY - JOUR
T1 - Interaction of porcine gastric mucin with various polycations and its influence on the boundary lubrication properties
AU - Nikogeorgos, Nikolaos
AU - Patil, Navinkumar J.
AU - Zappone, Bruno
AU - Lee, Seunghwan
PY - 2016
Y1 - 2016
N2 - The interaction of porcine gastric mucin (PGM) with polycations possessing amine functional groups,including polyallylamine hydrochloride (PAH), poly-l-lysine (PLL) and polyethylenimine (PEI), wasexamined from a tribological standpoint at a self-mated polydimethylsiloxane (PDMS) interface. In allcases, PGM interacted with the cationic polymers, leading to a smaller size of the aggregates compared toPGM, surface charge compensation, and distortion of the PGM protein conformation. But, a synergisticlubrication effect was clearly observed only from the 1/1 (w/w) mixture of PGM with branched PEI (BPEI)where the friction coefficient was reduced by two orders of magnitude compared to neat PGM or BPEIin the speed range of 0.25e100 mm/s. This was attributed to the smallest hydrodynamic size and“sphere-like” conformation of B-PEI due to high degree of branching, which favors tenacious complexationwith PGM, fast surface adsorption, and continuous reformation of the lubricating layer under cyclictribostress in pin-on-disc tribometry.
AB - The interaction of porcine gastric mucin (PGM) with polycations possessing amine functional groups,including polyallylamine hydrochloride (PAH), poly-l-lysine (PLL) and polyethylenimine (PEI), wasexamined from a tribological standpoint at a self-mated polydimethylsiloxane (PDMS) interface. In allcases, PGM interacted with the cationic polymers, leading to a smaller size of the aggregates compared toPGM, surface charge compensation, and distortion of the PGM protein conformation. But, a synergisticlubrication effect was clearly observed only from the 1/1 (w/w) mixture of PGM with branched PEI (BPEI)where the friction coefficient was reduced by two orders of magnitude compared to neat PGM or BPEIin the speed range of 0.25e100 mm/s. This was attributed to the smallest hydrodynamic size and“sphere-like” conformation of B-PEI due to high degree of branching, which favors tenacious complexationwith PGM, fast surface adsorption, and continuous reformation of the lubricating layer under cyclictribostress in pin-on-disc tribometry.
KW - Mucoadhesion
KW - Biolubrication
KW - Mucins
KW - PAH
KW - PEI
KW - PLL
U2 - 10.1016/j.polymer.2016.08.030
DO - 10.1016/j.polymer.2016.08.030
M3 - Journal article
SN - 0032-3861
VL - 100
SP - 158
EP - 168
JO - Polymer
JF - Polymer
ER -