Interaction of porcine gastric mucin with various polycations and its influence on the boundary lubrication properties

Nikolaos Nikogeorgos, Navinkumar J. Patil, Bruno Zappone, Seunghwan Lee

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Abstract

The interaction of porcine gastric mucin (PGM) with polycations possessing amine functional groups,including polyallylamine hydrochloride (PAH), poly-l-lysine (PLL) and polyethylenimine (PEI), wasexamined from a tribological standpoint at a self-mated polydimethylsiloxane (PDMS) interface. In allcases, PGM interacted with the cationic polymers, leading to a smaller size of the aggregates compared toPGM, surface charge compensation, and distortion of the PGM protein conformation. But, a synergisticlubrication effect was clearly observed only from the 1/1 (w/w) mixture of PGM with branched PEI (BPEI)where the friction coefficient was reduced by two orders of magnitude compared to neat PGM or BPEIin the speed range of 0.25e100 mm/s. This was attributed to the smallest hydrodynamic size and“sphere-like” conformation of B-PEI due to high degree of branching, which favors tenacious complexationwith PGM, fast surface adsorption, and continuous reformation of the lubricating layer under cyclictribostress in pin-on-disc tribometry.
Original languageEnglish
JournalPolymer
Volume100
Pages (from-to)158-168
ISSN0032-3861
DOIs
Publication statusPublished - 2016

Keywords

  • Mucoadhesion
  • Biolubrication
  • Mucins
  • PAH
  • PEI
  • PLL

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