Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen; Ulla Birgitte Vogel; Jane Christensen; Rikke D. Hansen; Håkan Wallin; Kim Overvad; Anne Tjønneland; Janne Tolstrup

doi:10.1016/j.canlet.2010.02.023

Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen, Ulla Birgitte Vogel, Jane Christensen, Rikke D. Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Tolstrup

National Food Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

Original language	English
Journal	Cancer Letters
Volume	295
Issue number	2
Pages (from-to)	191-197
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.canlet.2010.02.023
Publication status	Published - 2010

Keywords

Alcohol
Gene-environment interaction
Alcohol dehydrogenase
Breast cancer
Prospective study
Population-based study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2010.02.023

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Benzon Larsen, S., Vogel, U. B., Christensen, J., Hansen, R. D., Wallin, H., Overvad, K., Tjønneland, A., & Tolstrup, J. (2010). Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. Cancer Letters, 295(2), 191-197. https://doi.org/10.1016/j.canlet.2010.02.023

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title = "Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer",

abstract = "Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.",

keywords = "Alcohol, Gene-environment interaction, Alcohol dehydrogenase, Breast cancer, Prospective study, Population-based study",

author = "{Benzon Larsen}, Signe and Vogel, {Ulla Birgitte} and Jane Christensen and Hansen, {Rikke D.} and H{\aa}kan Wallin and Kim Overvad and Anne Tj{\o}nneland and Janne Tolstrup",

year = "2010",

doi = "10.1016/j.canlet.2010.02.023",

language = "English",

volume = "295",

pages = "191--197",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier",

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Benzon Larsen, S, Vogel, UB, Christensen, J, Hansen, RD, Wallin, H, Overvad, K, Tjønneland, A & Tolstrup, J 2010, 'Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer', Cancer Letters, vol. 295, no. 2, pp. 191-197. https://doi.org/10.1016/j.canlet.2010.02.023

Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. / Benzon Larsen, Signe; Vogel, Ulla Birgitte; Christensen, Jane et al.
In: Cancer Letters, Vol. 295, No. 2, 2010, p. 191-197.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

AU - Benzon Larsen, Signe

AU - Vogel, Ulla Birgitte

AU - Christensen, Jane

AU - Hansen, Rikke D.

AU - Wallin, Håkan

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Tolstrup, Janne

PY - 2010

Y1 - 2010

N2 - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

AB - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

KW - Alcohol

KW - Gene-environment interaction

KW - Alcohol dehydrogenase

KW - Breast cancer

KW - Prospective study

KW - Population-based study

U2 - 10.1016/j.canlet.2010.02.023

DO - 10.1016/j.canlet.2010.02.023

M3 - Journal article

C2 - 20350778

SN - 0304-3835

VL - 295

SP - 191

EP - 197

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Interaction between ADH1C Arg272Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Abstract

Keywords

UN SDGs

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