Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

R. Bergholdt; Zenia, Marian Størling; Kasper Lage Hansen; Erik, Olof, Linnart Karlberg; Páll Ísólfur Ólason; M. Aalund; J. Nerup; Søren Brunak; Christopher Workman; F. Pociot

doi:10.1186/gb-2007-8-11-r253

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

R. Bergholdt
, Zenia, Marian Størling
, Kasper Lage Hansen
, Erik, Olof, Linnart Karlberg
, Páll Ísólfur Ólason
, M. Aalund
, J. Nerup
, Søren Brunak
, Christopher Workman
, F. Pociot

NEurotech A/S
Lund University
Steno Diabetes Centre

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

Original language	English
Journal	Genome Biology
Volume	8
Issue number	11
Pages (from-to)	R253
ISSN	1465-6906
DOIs	https://doi.org/10.1186/gb-2007-8-11-r253
Publication status	Published - 2007

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SDG 3 Good Health and Well-being

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10.1186/gb-2007-8-11-r253

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title = "Integrative analysis for finding genes and networks involved in diabetes and other complex diseases",

abstract = "We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.",

author = "R. Bergholdt and St{\o}rling, \{Zenia, Marian\} and Hansen, \{Kasper Lage\} and Karlberg, \{Erik, Olof, Linnart\} and {\'O}lason, \{P{\'a}ll {\'I}s{\'o}lfur\} and M. Aalund and J. Nerup and S{\o}ren Brunak and Christopher Workman and F. Pociot",

year = "2007",

doi = "10.1186/gb-2007-8-11-r253",

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T1 - Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

AU - Bergholdt, R.

AU - Størling, Zenia, Marian

AU - Hansen, Kasper Lage

AU - Karlberg, Erik, Olof, Linnart

AU - Ólason, Páll Ísólfur

AU - Aalund, M.

AU - Nerup, J.

AU - Brunak, Søren

AU - Workman, Christopher

AU - Pociot, F.

PY - 2007

Y1 - 2007

N2 - We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

AB - We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

U2 - 10.1186/gb-2007-8-11-r253

DO - 10.1186/gb-2007-8-11-r253

M3 - Journal article

C2 - 18045462

SN - 1465-6906

VL - 8

SP - R253

JO - Genome Biology

JF - Genome Biology

IS - 11

ER -

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

Abstract

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