Abstract
We present a novel strategy for thrombin detection by combining a magnetic bead based agglutination assay and low-cost microfluidic disc. The detection method is based on an optomagnetic readout system implemented using a Blu-ray optical pickup unit (OPU) as main optoelectronic component. The assay, from sample to answer, is fully integrated on a microfluidic disc which embeds on-disc mixing ensuring full automation of the assay along with less sample-to-answer time compared to similar methods. Moreover, we compare the optomagnetic readout to the cluster size distribution determined using a commercial optical scanning imaging instrument.
Original language | English |
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Title of host publication | Proceedings of MicroTAS 2015 |
Number of pages | 3 |
Publication date | 2015 |
Pages | 1807-1809 |
Publication status | Published - 2015 |
Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Hwabaek International Convention Center, Gyeongju-si, Korea, Republic of Duration: 25 Oct 2015 → 29 Oct 2015 Conference number: 19 https://mtas.hdasan.com/ |
Conference
Conference | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
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Number | 19 |
Location | Hwabaek International Convention Center |
Country/Territory | Korea, Republic of |
City | Gyeongju-si |
Period | 25/10/2015 → 29/10/2015 |
Internet address |
Keywords
- Agglutination assay
- Aptamer
- Magnetic beads
- Centrifugal Microfluidics
- Thrombin
- Microfluidic disc