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We demonstrate the first light sheet microscope using propagation invariant, accelerating Airy beams that operates both in single- and two-photon modes. The use of the Airy beam permits us to develop an ultra compact, high resolution light sheet system without beam scanning. In two-photon mode, an increase in the field of view over the use of a standard Gaussian beam by a factor of six is demonstrated. This implementation for light sheet microscopy opens up new possibilities across a wide range of biomedical applications, especially for the study of neuronal processes.
Piksarv, P., Marti, D., Le, T., Unterhuber, A., Forbes, L. H., Andrews, M. R., Stingl, A., Drexler, W., Andersen, P. E., & Dholakia, K. (2017). Integrated single- and two-photon light sheet microscopy using accelerating beams. Scientific Reports, 7(1), . https://doi.org/10.1038/s41598-017-01543-4