Intake of unprocessed and processed meat and the association with cardiovascular disease: An overview of systematic reviews

Marianne Uhre Jakobsen*, Anette Bysted, Heddie Mejborn, Anders Stockmarr, Ellen Trolle

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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Abstract

We conducted an overview of systematic reviews to summarize reviews of cohort studies on intake of unprocessed and processed meat and the risk of cardiovascular disease (CVD), coronary heart disease (CHD), and stroke. Systematic reviews of cohort studies published between January 2010 and August 2020 were identified through a systematic literature search in PubMed, Embase, and Web of Science. The quality of how each review was conducted was assessed and the overall confidence in the results of each review was rated using AMSTAR 2. The quality of evidence of each meta-analysis was graded using NutriGrade. Three reviews were included, with meta-analyses of unprocessed red meat and CVD (n = 1) and stroke (n = 2); unprocessed poultry and stroke (n = 1); and processed meat and CVD (n = 1), CHD (n = 1), and stroke (n = 3). The overall confidence in the results of each review was rated as critically low. The meta-evidence was graded moderate for a positive association between unprocessed red meat and stroke and moderate for a positive association between processed meat and CHD and stroke. For other associations the meta-evidence was graded as low or very low. In conclusion, the associations between unprocessed and processed meat with CVD and major subtypes of CVD have not been extensively investigated.

Original languageEnglish
Article number3303
JournalNutrients
Volume13
Issue number10
Number of pages19
ISSN2072-6643
DOIs
Publication statusPublished - Oct 2021

Bibliographical note

Funding Information:
Funding: This overview was funded by the Ministry of Food, Agriculture and Fisheries of Denmark. The Ministry of Food, Agriculture and Fisheries of Denmark has not been involved in the planning or conduct of the review.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Cardiovascular disease
  • Diet
  • Poultry
  • Red meat
  • Systematic overview

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