Insulin dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

A. Pause, Graham Belsham, A.-C. Gingras, O. Donze, T.-A. Lin, Jr. J. C. Lawrence, N. Sonenberg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.
Original languageEnglish
JournalNature
Volume371
Issue number6500
Pages (from-to)762-767
ISSN0028-0836
DOIs
Publication statusPublished - 1994
Externally publishedYes

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