Insulin dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

A. Pause; Graham Belsham; A.-C. Gingras; O. Donze; T.-A. Lin; Jr. J. C. Lawrence; N. Sonenberg

doi:10.1038/371762a0

Insulin dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

A. Pause, Graham Belsham, A.-C. Gingras, O. Donze, T.-A. Lin, Jr. J. C. Lawrence, N. Sonenberg

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Abstract

The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.

Original language	English
Journal	Nature
Volume	371
Issue number	6500
Pages (from-to)	762-767
ISSN	0028-0836
DOIs	https://doi.org/10.1038/371762a0
Publication status	Published - 1994
Externally published	Yes

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title = "Insulin dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function",

abstract = "The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.",

author = "A. Pause and Graham Belsham and A.-C. Gingras and O. Donze and T.-A. Lin and Lawrence, {Jr. J. C.} and N. Sonenberg",

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T1 - Insulin dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

AU - Pause, A.

AU - Belsham, Graham

AU - Gingras, A.-C.

AU - Donze, O.

AU - Lin, T.-A.

AU - Lawrence, Jr. J. C.

AU - Sonenberg, N.

PY - 1994

Y1 - 1994

N2 - The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.

AB - The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.

U2 - 10.1038/371762a0

DO - 10.1038/371762a0

M3 - Journal article

SN - 0028-0836

VL - 371

SP - 762

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JO - Nature

JF - Nature

IS - 6500

ER -

Insulin dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

Abstract

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