Inkjet printing as a technique for filling of micro-wells with biocompatible polymers

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    Abstract

    We present an innovative technique to dispense precise amounts of polymer solutions into large arrays of microscopic wells. An inkjet printer (NP 2.1 GeSim, Germany) is used to fill micro-wells with poly (vinyl pyrrolidone) (PVP K10). The micro-wells are fabricated with cavity diameters of 300 μm down to 50 μm with SU-8 with two steps of negative photolithography. Inkjet printing is shown to be a suitable technique to dispense defined volumes of solution (down to 0.3 nL) in a highly reproducible way. The filling with polymer can be controlled varying the concentration of the solution and the number of dispensed droplets. Solutions of up to 20 wt.% PVP in water are successfully spotted.
    Original languageEnglish
    JournalMicroelectronic Engineering
    Volume111
    Pages (from-to)391-395
    ISSN0167-9317
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Inkjet printing
    • Micro-wells
    • PVP
    • Drug delivery

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