Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones

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@article{24353875116e48348168b877e81d4745,
title = "Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones",
abstract = "To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS). All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures. Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14{\%} over the sensor area (2 × 2 mm2), and a 18{\%} signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.",
keywords = "SERS, SERS substrates, Chemical sensing, Lab-on-a-chip, Microfluidics, Plasmonic, Polymer injection molding",
author = "Marlitt Viehrig and Thilsted, {Anil H.} and Marco Matteucci and Kaiyu Wu and Darmin Catak and Schmidt, {Michael S.} and Kinga Zor and Anja Boisen",
year = "2018",
doi = "10.1021/acsami.8b13424",
language = "English",
volume = "10",
pages = "37417--37425",
journal = "A C S Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "43",

}

RIS

TY - JOUR

T1 - Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones

AU - Viehrig, Marlitt

AU - Thilsted, Anil H.

AU - Matteucci, Marco

AU - Wu, Kaiyu

AU - Catak, Darmin

AU - Schmidt, Michael S.

AU - Zor, Kinga

AU - Boisen, Anja

PY - 2018

Y1 - 2018

N2 - To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS). All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures. Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14% over the sensor area (2 × 2 mm2), and a 18% signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.

AB - To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS). All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures. Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14% over the sensor area (2 × 2 mm2), and a 18% signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.

KW - SERS

KW - SERS substrates

KW - Chemical sensing

KW - Lab-on-a-chip

KW - Microfluidics

KW - Plasmonic

KW - Polymer injection molding

U2 - 10.1021/acsami.8b13424

DO - 10.1021/acsami.8b13424

M3 - Journal article

VL - 10

SP - 37417

EP - 37425

JO - A C S Applied Materials and Interfaces

JF - A C S Applied Materials and Interfaces

SN - 1944-8244

IS - 43

ER -