Injection molded pinched flow fractionation device for enrichment of somatic cells in cow milk

Marie Pødenphant Jensen, Rodolphe Marie, Tom Olesen, Marco Matteucci, Anders Kristensen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    In this paper the continuous microfluidic separation technique pinched flow fractionation is applied to the enrichment of somatic cells from cow milk. Somatic cells were separated from the smallest fat particles and proteins thus better imaging and analysis of the cells can be achieved. The enrichment was performed using an all-polymer pinched flow fractionation device fabricated by injection molding. The polymer chips were bonded to a 500 lm polymer foil using UV assisted thermal bonding. The quality of the final devices was reproducible and the injection molding process combined with the use of cheap materials ensures the possibility for device mass production
    Original languageEnglish
    JournalMicroelectronic Engineering
    Volume124
    Pages (from-to)53-57
    Number of pages5
    ISSN0167-9317
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Pinched flow fractionation
    • Microfluidics
    • Injection molding
    • Somatic cells
    • TOPAS

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