Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones

Marlitt Viehrig, Anil H. Thilsted, Marco Matteucci, Kaiyu Wu*, Darmin Catak, Michael S. Schmidt, Kinga Zor, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS). All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures. Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14% over the sensor area (2 × 2 mm2), and a 18% signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.
Original languageEnglish
JournalACS Applied Materials and Interfaces
Volume10
Issue number43
Pages (from-to)37417-37425
ISSN1944-8244
DOIs
Publication statusPublished - 2018

Keywords

  • SERS
  • SERS substrates
  • Chemical sensing
  • Lab-on-a-chip
  • Microfluidics
  • Plasmonic
  • Polymer injection molding

Cite this

Viehrig, Marlitt ; Thilsted, Anil H. ; Matteucci, Marco ; Wu, Kaiyu ; Catak, Darmin ; Schmidt, Michael S. ; Zor, Kinga ; Boisen, Anja. / Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones. In: ACS Applied Materials and Interfaces. 2018 ; Vol. 10, No. 43. pp. 37417-37425.
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title = "Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones",
abstract = "To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS). All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures. Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14{\%} over the sensor area (2 × 2 mm2), and a 18{\%} signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.",
keywords = "SERS, SERS substrates, Chemical sensing, Lab-on-a-chip, Microfluidics, Plasmonic, Polymer injection molding",
author = "Marlitt Viehrig and Thilsted, {Anil H.} and Marco Matteucci and Kaiyu Wu and Darmin Catak and Schmidt, {Michael S.} and Kinga Zor and Anja Boisen",
year = "2018",
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journal = "A C S Applied Materials and Interfaces",
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Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones. / Viehrig, Marlitt; Thilsted, Anil H.; Matteucci, Marco; Wu, Kaiyu; Catak, Darmin; Schmidt, Michael S.; Zor, Kinga; Boisen, Anja.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 43, 2018, p. 37417-37425.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Viehrig, Marlitt

AU - Thilsted, Anil H.

AU - Matteucci, Marco

AU - Wu, Kaiyu

AU - Catak, Darmin

AU - Schmidt, Michael S.

AU - Zor, Kinga

AU - Boisen, Anja

PY - 2018

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N2 - To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS). All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures. Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14% over the sensor area (2 × 2 mm2), and a 18% signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.

AB - To enable affordable detection and diagnostic, there is a need for low-cost and mass producible miniaturized sensing platforms. We present a fully polymeric microfluidic lab-on-a-chip device with integrated gold (Au)-capped nanocones for sensing applications based on surface-enhanced Raman spectroscopy (SERS). All base components of the device were fabricated via injection molding (IM) and can be easily integrated using ultrasonic welding. The SERS sensor array, embedded in the bottom of a fluidic channel, was created by evaporating Au onto IM nanocone structures, resulting in densely packed Au-capped SERS active nanostructures. Using a Raman active model analyte, trans-1,2-bis-(4-pyridyl)-ethylene, we found a surface-averaged SERS enhancement factor of ∼5 × 106 with a relative standard deviation of 14% over the sensor area (2 × 2 mm2), and a 18% signal variation among substrates. This reproducible fabrication method is cost-effective, less time consuming, and allows mass production of fully integrated polymeric, microfluidic systems with embedded high-density and high-aspect ratio SERS sensor.

KW - SERS

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KW - Plasmonic

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