Initial lung lesions in two calves experimentally infected with Haemophilus somnus

Conny Tegtmeier, B. Bloch, N.E. Jensen, H.E. Jensen

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    The initial lung lesions in two calves intrabronchially inoculated with Haemophilus somnus are described. The animals were euthanized wit hin 7 h after challenge. The in situ location of H. somnus and accompanying lesions were examined by light microscopy, immunohistochemistry and transmission electron microscopy (TEM). Inoculation with H. somnus resulted in the development of acute pulmonary lesions within 3.5 h. H. somnus antigen was demonstrated only within the luminal spaces of the airways and in one area of bronchio-associated lymphoid tissue (BALT). As observed by TEM, the bacteria were phagocytized by both neutrophils and alveolar macrophages. Antigen was never demonstrated in the pulmonary intravascular macrophages.
    Original languageEnglish
    JournalJournal of Veterinary Medicine Series B-Infectious Diseases and Veterinary Public Health
    Issue number8
    Pages (from-to)517-523
    Publication statusPublished - 1999


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