Infrared neural stimulation and electrophysiology in a soft fiber-based neural interface

Marcello Meneghetti, Kunyang Sui, Jaspreet Kaur, Jakob F. Sørensen, Rune W. Berg, Christos Markos

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Abstract

Infrared neurostimulation has emerged in recent years as a promising technique for controlling neuronal activity without genetic manipulation. Having high absorption of the employed wavelengths as its fundamental mechanism, it requires implantable platforms to deliver light in brain regions deeper than the first cortical layers. Due to the spatial confinement of the stimulation, electrodes integrated in close proximity to the illumination spot are desirable to verify the effects of the stimulation by extracellular electrophysiology. Here we developed and validated in vivo a multifunctional neural interface based on a soft, biocompatible polymer optical fiber that allows simultaneous infrared neurostimulation and electrophysiology.
Original languageEnglish
Title of host publicationProceedings of SPIE
Number of pages7
Volume12366
PublisherSPIE - International Society for Optical Engineering
Publication date2023
Article number1236605
DOIs
Publication statusPublished - 2023
SeriesProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN1605-7422

Keywords

  • Extracellular electrophysiology
  • Infrared neurostimulation
  • Multifunctional neural interfaces
  • Polymer optical fibers

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