TY - JOUR
T1 - Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers
AU - Saber, Anne Thoustrup
AU - Koponen, Ismo Kalevi
AU - Jensen, Keld Alstrup
AU - Jacobsen, Nicklas Raun
AU - Mikkelsen, Lone Rømer
AU - Moller, Peter
AU - Loft, Steffen
AU - Vogel, Ulla Birgitte
AU - Wallin, Hakan
PY - 2012
Y1 - 2012
N2 - Nanoparticles are increasingly used in paints and lacquers. Little is known of the toxicity of nanoparticles incorporated in complex matrices and released during different phases of the life cycle. DNA damaging activity and inflammogenicity of sanding dust sampled during standardised sanding of boards painted with paints with and without nanoparticles were determined 24 h after intratracheal instillation of a single dose of 54 mu g in mice. Dusts from nanoparticle-containing paints and lacquers did not generate pulmonary inflammation or oxidative stress. Sanding dust from both the nanoparticle-containing and the conventional lacquer and the outdoor acrylic-based reference paint increased the level of DNA strand breaks in bronchoalveolar fluid cells. In conclusion, addition of nanoparticles to paint or lacquers did not increase the potential of sanding dust for causing inflammation, oxidative stress or DNA damage, suggesting that the paint/lacquer matrix is more important as determinant of DNA damage than the nanomaterial.
AB - Nanoparticles are increasingly used in paints and lacquers. Little is known of the toxicity of nanoparticles incorporated in complex matrices and released during different phases of the life cycle. DNA damaging activity and inflammogenicity of sanding dust sampled during standardised sanding of boards painted with paints with and without nanoparticles were determined 24 h after intratracheal instillation of a single dose of 54 mu g in mice. Dusts from nanoparticle-containing paints and lacquers did not generate pulmonary inflammation or oxidative stress. Sanding dust from both the nanoparticle-containing and the conventional lacquer and the outdoor acrylic-based reference paint increased the level of DNA strand breaks in bronchoalveolar fluid cells. In conclusion, addition of nanoparticles to paint or lacquers did not increase the potential of sanding dust for causing inflammation, oxidative stress or DNA damage, suggesting that the paint/lacquer matrix is more important as determinant of DNA damage than the nanomaterial.
U2 - 10.3109/17435390.2011.620745
DO - 10.3109/17435390.2011.620745
M3 - Journal article
C2 - 21995293
SN - 1743-5390
VL - 6
SP - 776
EP - 788
JO - Nanotoxicology
JF - Nanotoxicology
IS - 7
ER -