Infinite Relational Modeling of Functional Connectivity in Resting State fMRI

Morten Mørup, Kristoffer H. Madsen, Anne Marie Dogonowski, Hartwig Siebner, Lars Kai Hansen

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    Abstract

    Functional magnetic resonance imaging (fMRI) can be applied to study the functional connectivity of the neural elements which form complex network at a whole brain level. Most analyses of functional resting state networks (RSN) have been based on the analysis of correlation between the temporal dynamics of various regions of the brain. While these models can identify coherently behaving groups in terms of correlation they give little insight into how these groups interact. In this paper we take a different view on the analysis of functional resting state networks. Starting from the definition of resting state as functional coherent groups we search for functional units of the brain that communicate with other parts of the brain in a coherent manner as measured by mutual information. We use the infinite relational model (IRM) to quantify functional coherent groups of resting state networks and demonstrate how the extracted component interactions can be used to discriminate between functional resting state activity in multiple sclerosis and normal subjects.
    Original languageEnglish
    Title of host publicationNeural Information Processing Systems : (NIPS)
    Volume23
    Publication date2010
    Publication statusPublished - 2010
    Event24th Annual Conference on Neural Information Processing Systems - Vancouver, Canada
    Duration: 6 Dec 201011 Dec 2010
    Conference number: 24
    http://nips.cc/Conferences/2010/

    Conference

    Conference24th Annual Conference on Neural Information Processing Systems
    Number24
    CountryCanada
    CityVancouver
    Period06/12/201011/12/2010
    Internet address

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